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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Behav Brain Res. 2018 Jul 24;359:836–844. doi: 10.1016/j.bbr.2018.07.019

Figure 5.

Figure 5

Effects of adolescent and adult nicotine exposure on breakpoints. Bars depict mean ± SEMs for 3-day PR testing averages of breakpoints for each saline/nicotine exposure condition. Post hoc tests for adolescent nicotine × adult nicotine × reinforcement interactions: *, **, p<0.05, 0.01 sacch reinforcement vs nic reinforcement (within subjects) comparisons for sal/nic, nic/sal and nic/nic; ‡‡, p<0.01 sal/sal vs nic/nic (sacch reinforcement; between subjects); ‡‡‡, p<0.001 nic/sal vs sal/nic and nic/nic (sacch reinforcement; between subjects). sal/sal: adolescent saline-exposed mice re-exposed to saline in adulthood; sal/nic: adolescent saline-exposed mice re-exposed to nicotine in adulthood; nic/sal: adolescent nicotine-exposed mice re-exposed to saline in adulthood; nic/nic: adolescent nicotine-exposed mice re-exposed to nicotine in adulthood; sacch: saccharin; nic: nicotine.