Table 1: Within-session and Across-session ICCs as Measured via GEKO, and Inter-grader ICCs as Measured via GEKO and Manual Grading.

Data are presented as mean +/− 95% confidence intervals. A * indicates a significant difference between manual and GEKO grading (p<0.05). Graders 2 and 4 were unavailable for manual grading due to a change of employment; Grader 5 was added to assure a minimum of three graders for this follow-up experiment.

		Within-Session Reproducibility ICCs (Images repeated within a session)				Across-Session Reproducibility ICCs (42 image set)					Inter-Grader Reliability ICCs (42 image set)
	Grader				All Graders Mean (95% CI)	Grader				All Graders Mean (95% CI)	GEKO (Graders 1, 3, & 5)	Manual (Graders 1, 3, & 5)
Histological Gradess	1	2	3	4		1	2	3	4
Tibial Plateau Width (μm)	0.907	0.814	0.900	0.826	0.862 (0.785–0.939)	0.927	0.874	0.949	0.845	0.899 (0.823–0.975)	0.916 (0.859–0.952)	0.873 (0.736–0.910)
Surface Cartilage Matrix Loss Width (μm)	0.982	0.844	0.864	0.983	0.918 (0.799–1.000)	0.944	0.845	0.676	0.958	0.856 (0.649–1.000)	0.820 (0.654–0.900)	0.966 (0.944–0.981)*
Middle Cartilage Matrix Loss Width (μm)	0.965	0.714	0.893	0.995	0.892 (0.692–1.000)	0.958	0.931	0.643	0.972	0.876 (0.627–1.000)	0.944 (0.905–0.969)*	0.645 (0.405–0.799)
Deep Cartilage Matrix Loss Width (μm)	0.943	NV	0.862	0.992	0.932 (0.769–1.000)	0.714	0.760	0.733	0.811	0.755 (0.687–0.822)	0.535 (0.208–0.740)	0.867 (0.777–0.924)*
Total Cartilage Degeneration Width (% of Tibial Plateau)	0.988	0.995	0.996	0.947	0.982 (0.944–1.000)	0.965	0.995	0.994	0.849	0.951 (0.841–1.000)	0.983 (0.971–0.990)	0.977 (0.965–0.988)
Osteophyte Size (μm)	0.995	0.998	0.961	0.986	0.985 (0.958–1.000)	0.985	0.995	0.984	0.981	0.986 (0.977–0.996)	0.971 (0.952–0.984)	0.982 (0.977–0.990)
Medial Joint Capsule Repair (μm)	0.957	0.976	0.986	0.965	0.971 (0.951–0.991)	0.944	0.971	0.977	0.963	0.964 (0.941–0.987)	0.939 (0.899–0.965)	0.985 (0.825–0.940)