Table 2: Histological Grades Using Manual Grading and GEKO.
Data are presented as mean +/− 95% confidence intervals.
| Histological Grades |
Naive | Sham | MMT – Week 1 | MMT – Week 2 | MMT – Week 4 | MMT – Week 6 | |
|---|---|---|---|---|---|---|---|
| Tibial Plateau Width (μm) | Manual | 2298 (2175–2421) | 2409 (2304–2514) | 2418 (2296–2540) | 2417 (2276–2557) | 2609 (2464–2753) | 2602 (2405- 2798) |
| GEKO | 2310 (2194–2425) | 2401 (2292–2522) | 2417 (2274–2559) | 2429 (2278–2580) | 2700 (2540–2859) | 2590 (2379- 2801) | |
| Surface Cartilage Matrix Loss Width (μm) | Manual | 0 (0–0) | 109 (0–338) | 744 (560–928) | 789 (376–1202) | 1041 (832–1250) | 987 (649–1326) |
| GEKO | 0 (0–0) | 78 (0–241) | 467 (319–615) | 360 (167–553) | 780 (566–994) | 905 (417–1393) | |
| Middle Cartilage Matrix Loss Width (μm) | Manual | 0 (0–0) | 40 (0–125) | 128 (59–196) | 133 (25–242) | 183 (11–356) | 208 (75–342) |
| GEKO | 0 (0–0) | 93 (0–289) | 336 (166–506) | 477 (111–842) | 426 (204–647) | 472 (145–800) | |
| Deep Cartilage Matrix Loss Width (μm) | Manual | 0 (0–0) | 37 (0–115) | 75 (30–120) | 69 (7–132) | 103 (0–217) | 101 (0–209) |
| GEKO | 0 (0–0) | 16 (0–48) | 13 (0–43) | 66 (0–147) | 19 (0–48) | 16 (0–33) | |
| Total Cartilage Degeneration Width (% of Tibial Plateau) | Manual | 0 (0–1) | 5 (0–15) | 54 (47–61) | 49 (29–70) | 55 (50–59) | 54 (48–61) |
| GEKO | 0 (0–0) | 5 (0–15) | 47 (41–53) | 44 (26–63) | 50 (47–54) | 48 (36–61) | |
| Osteophyte Size (μm) | Manual | 0 (0–0) | 53 (0–163) | 0 (0–0) | 152 (0–326) | 538 (376–700) | 480 (307–652) |
| GEKO | 0 (0–0) | 55 (0–156) | 0 (0–0) | 183 (41–324) | 512 (368–656) | 481 (364–598) | |
| Medial Joint Capsule Repair (μm) | Manual | 386 (351–420) | 501 (407–595) | 688 (523–854) | 519 (353–686) | 517 (424–609) | 557 (351–762) |
| GEKO | 383 (322–445) | 507(407–606) | 713 (551–876) | 552 (365–739) | 535 (410–659) | 529 (363–694) |