Table 3:

Association of maternal gestational smoking and residual duration of exclusive breastfeeding^¥ with eczema at ages 1-or-2, 4, 10, and 18 adjusted for covariates.

	Outcome: Eczema prevalence at all the time points (k=3777)			Outcome: Eczema persistence at all three transitions (k=2331)
Parameter	Levels	Risk ratio (95% CI)	p- value		Risk ratio (95% CI)	p- value
Maternal gestational smoking		0.81 (0.6, 1.1)	0.15		0.61 (0.36, 1.06)	0.08
Residual exclusive breastfeeding duration		1.0 (0.9, 1.01)	0.9		0.99 (0.98, 1.01)	0.75
Maternal gestational smoking ×
Residual exclusive breastfeeding duration#*	0 weeks	0.8 (0.6, 1.1)	0.15		0.6, (0.36, 1.06)	0.08
	≥ 3 weeks	0.7 (0.5, 1.0)	0.06		0.5 (0.3, 0.9)	0.04
	≥ 9 weeks	0.6 (0.4, 0.9)	0.02		0.4 (0.2, 0.8)	0.01
	≥ 15 weeks	0.5 (0.3, 0.8)	0.02		0.3 (0.1, 0.8)	0.01
	≥ 21 weeks	0.4 (0.2, 0.8)	0.02		0.2 (0.08, 0.7)	0.01
FLG loss of function variants		1.6 (1.2, 2.1)	0.003		1.9 (1.19, 3.05)	0.007
Time	Age 1-or-2	Ref.	Ref.	Transition 1	Ref.	Ref.
				(1-or-2 to 4 years)
	Age 4	0.7 (0.62, 0.9)	0.001	Transition 2	1.02 (0.97, 1.1)	0.4
				(4 to 10 years)
	Age 10	0.9 (0.8, 1.1)	0.5	Transition 3	0.89 (0.74, 1.1)	0.2
				(10 to 18 years)
	Age 18	0.76 (0.6, 0.9)	0.007
Weeks of gestation		1.1 (1.0, 1.2)	0.03		1.1 (0.9, 1.3)	0.24
Maternal eczema status		1.3 (0.9, 1.8)	0.06		1.2 (0.75, 2.1)	0.4
Paternal eczema status		1.7 (1.3, 2.4)	0.001		2.1 (1.2, 3.5)	0.004
Gender (Female is reference)	Male	0.9 (0.7, 1.2)	0.57		0.9 (0.7, 1.4)	0.9
Socio economic status  (high is reference)	Mid	0.9 (0.7, 1.4)	0.9		1.02 (0.6, 1.9)	0.9
	Low	0.9 (0.6, 1.4)	0.7		0.8 (0.35, 1.8)	0.6

^¥Residuals are calculated by regressing exclusive breastfeeding duration on maternal gestational smoking.

^#Overall p-value is 0.04 when the outcome is eczema prevalence at ages 1-or-2, 4, 10, and 18 years.

^*Overall p-value is 0.03 when the outcome is persistent eczema for all transitions from age 1-or-2 to 4 years, age 4 to 10 years, age 10 to 18 years