Table 3:

Linear regression analysis of blood pressure variability, heart rate variability, catecholamines and metanephrines adjusted for factors affecting sympathetic activity in patients with controlled and masked uncontrolled hypertension in- and out-of- clinic

	p-value
	In-Clinic			Out-of-clinic
Variables	Unadjusted	Adjusted for diabetes & αβ-blockers	Multivariable adjusted *	Unadjusted	Adjusted for diabetes & αβ-blockers	Multivariable adjusted *
Blood Pressure/Heart Rate
Awake (Day-time)
Systolic BP † variability (mmHg)				<0.001	<0.001	<0.001
Diastolic BP † variability (mmHg)				<0.001	<0.001	<0.001
Heart rate variability (beats/minute)				<0.001	<0.001	<0.001
Asleep (Night-time)
Systolic BP † variability (mmHg)				<0.001	<0.001	<0.001
Diastolic BP † variability (mmHg)				<0.001	<0.001	<0.001
Heart rate variability (beats/minute)				<0.001	<0.001	<0.001
24-hr (Overall)
Systolic BP † variability (mmHg)				<0.001	<0.001	<0.001
Diastolic BP † variability (mmHg)				<0.001	<0.001	<0.001
Heart rate variability (beats/minute)				0.001	0.001	0.001
Catechoamines/Metanephrines
Epinephrine
- Urine				0.693	0.671	0.571
- Plasma	0.297	0.500	0.983
Norepinephrine
- Urinary				0.032	0.031	0.048
- Plasma	0.275	0.319	0.365
Total Catecholamines (Epinephrine & Norepinephrine)
- Urinary				0.030	0.030	0.049
- Plasma	0.304	0.348	0.411
Metanephrine
- Urinary	0.785	0.914	0.886	0.030	0.017	0.017
- Plasma	0.748	0.497	0.642
Normetanephrine
- Urinary	0.990	0.938	0.846	0.017	0.008	0.009
- Plasma	0.408	0.239	0.329
Total Metanephrines (Metanephrine & Normetanephrine)
- Urinary	0.919	0.921	0.838	0.008	0.004	0.004

^*Multivariable adjusted for diabetes, BMI, smoking, calcium channel blockers, β-blockers, αβ-blockers and α2-agonist

^†BP, blood pressure