Table 2.
Test characteristics of the HEART Pathway and its components for detection of death and MI from index through 30 days.
| Sensitivity (95% CI) |
Specificity (95% CI) |
PPV (95% CI) |
NPV (95% CI) |
+LR (95% CI) |
-LR (95% CI) |
|
|---|---|---|---|---|---|---|
| HEART Pathway | 98.3% (96.3–99.4%) | 39.9% (38.3–41.5%) | 13.5% (12.2–14.9%) | 99.6% (99.1–99.9%) | 1.64 (1.59–1.68) | 0.04 (0.01–0.08) |
| HEAR Score | 83.6% (78.9–87.6%) | 43.0% (41.4–44.7%) | 11.0% (9.7–12.3% | 96.9% (95.9–97.7%) | 1.47 (1.38–1.55) | 0.38 (0.29–0.49) |
| Troponin | 91.8% (88.4–94.5) | 87.7% (86.6–88.8) | 42.6% (39.0–46.2) | 99.1% (98.7–99.4) | 7.49 (6.81–8.23) | 0.09 (0.07–0.13) |
HEART Pathway; low-risk determined by HEAR score <4, and no known CAD, and no acute ischemic ECG changes, and no troponin elevation at 0 or 3 hours. Non-low-risk determined by HEAR score ≥4, or known CAD, or an acute ischemic ECG change, or a troponin elevation at 0 or 3 hours.
HEAR Score; low risk determined by a HEAR score <4, and no known CAD, and no acute ischemic ECG changes. Non-low-risk determined by HEAR score ≥4, or known CAD, or an acute ischemic ECG change.
Troponin; low-risk determined by no troponin elevation at 0 or 3 hours. Non-low-risk determined by a troponin elevation at 0 or 3 hours.
CAD= coronary artery disease, ECG= electrocardiogram, PPV= positive predictive value, NPV=negative predictive value, +LR= positive likelihood ratio, -LR= negative likelihood ratio