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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Antiviral Res. 2017 Dec 14;150:93–100. doi: 10.1016/j.antiviral.2017.12.006

Table 12.

Among studies of immunological and non-immunological host factors, research on nonimmunological host factors was considered to be a secondary priority for discovering a cure for chronic hepatitis B.

Non-Immunological Host Factors
Project Rank
More complete understanding of the HBV life cycle, from receptor binding and entry, to nuclear transport and uncoating, and morphogenesis and secretion of virus and particles, with a focus on steps that are vulnerable to intervention 1
Determination of if and how information about the role of host factors in HBV virology can be used in the management (treatment and risk assessments) of HBV disease 1
Role of viral genotypes in pathogenicity, natural history and responsiveness to therapy 1
Role of host factors in determining outcomes (acute versus chronic, responsiveness to therapies, development of disease 2
Role of genetic factors in determining outcomes of disease natural history and responsiveness to therapy 2