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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Antiviral Res. 2017 Dec 14;150:93–100. doi: 10.1016/j.antiviral.2017.12.006

Table 8.

Research on HBV DNA integration into the host cell chromosomes was considered to be a secondary priority for discovering a cure for chronic hepatitis B.

Integrated HBV DNA
Project Rank
Can integrated HBV DNA cause independent production of HBsAg, making loss of HBsAg and/or measuring levels of HBsAg in some persons not a useful treatment endpoint or functional cure? 1
How can information about integrated HBV DNA be used in the management (treatment and risk assessments) of disease? 1
Better understanding of the role integrated HBV DNA plays in oncogenesis and in contributing gene products that affect chronic liver disease 2
Determination of the mechanism of regulation of integrated DNA expression 2