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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: J Pathol. 2017 Oct 3;243(3):390–400. doi: 10.1002/path.4960

Figure 5.

Figure 5.

(A) Alterations in TGFβ/BMP receptor expression in MC mono-3D culture, in response to TGFβ (10 ng/ml) and BMP7 (100 ng/ml) stimulation and co-stimulation, measured by quantitative reverse transcriptase PCR analysis (n=3; error bars represent 1 s.d.; ***, p<0.001 *; p<0.05: 2-tailed Student’s t test). (B) Phospho-SMAD (1, 2 and 3) activity in glomeruli from normal human kidney, diabetic nephropathy or focal segmental glomerulosclerosis (FSGS). Representative immunohistochemistry images and quantification by percentage of positive nuclei per glomerulus (diabetic nephropathy, n=3; FSGS, n=3; control tissue, n=6). p values are for comparison of diseased to normal tissue, using 2-tailed Student’s t test.