Table 5.
Association between anti-CA15.3 and anti-CA125 antibodies in perspective of CA15.3 and CA125 level.
| Antigen/ antibody combinations | All |
<3 years between blood and diagnosis |
≥3 years between blood and diagnosis |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls N (%) | Cases N (%) | OR (95% CI) | p | ControlsN (%) | Cases N (%) | OR (95% CI) | p | ControlsN (%) | Cases N (%) | OR (95% CI) | p | |
| CA15.3/anti-CA15.3 antibodies | ||||||||||||
| All EOC | ||||||||||||
| Low/low | 457 (23.8) | 207 (25.7) | 1.00 (referent) | 168 (23.7) | 44 (22.8) | 1.00 (referent) | 289 (23.9) | 163 (26.7) | 1.00 (referent) | |||
| High/low | 502 (26.2) | 210 (26.1) | 0.93 (0.74, 1.18) | 0.57 | 172 (24.3) | 51 (26.4) | 1.20 (0.75, 1.90) | 0.45 | 330 (27.3) | 159 (26.0) | 0.86 (0.65, 1.13) | 0.26 |
| Low/high | 503 (26.2) | 184 (22.9) | 0.83 (0.66, 1.05) | 0.13 | 200 (28.2) | 45 (23.3) | 0.90 (0.57, 1.44) | 0.66 | 303 (25.0) | 139 (22.7) | 0.82 (0.62, 1.07) | 0.14 |
| High/high | 457 (23.8) | 203 (25.2) | 1.00 (0.79, 1.27) | 0.99 | 169 (23.8) | 53 (27.5) | 1.23 (0.77, 1.97) | 0.38 | 288 (23.8) | 150 (24.5) | 0.93 (0.71, 1.22) | 0.61 |
| All EOC, premenopausal | ||||||||||||
| Low/low | 133 (27.8) | 56 (27.9) | 1.00 (referent) | 48 (28.2) | 7 (15.2) | 1.00 (referent) | 85 (27.5) | 49 (31.6) | 1.00 (referent) | |||
| High/low | 114 (23.8) | 49 (24.4) | 1.02 (0.64, 1.62) | 0.93 | 41 (24.1) | 14 (30.4) | 2.01 (0.74, 5.47) | 0.17 | 73 (23.6) | 35 (22.6) | 0.84 (0.49, 1.43) | 0.51 |
| Low/high | 132 (27.6) | 55 (27.4) | 1.01 (0.65, 1.58) | 0.95 | 43 (25.3) | 16 (34.8) | 2.69 (1.01, 7.14) | 0.05 | 89 (28.8) | 39 (25.2) | 0.76 (0.45, 1.26) | 0.28 |
| High/high | 100 (20.9) | 41 (20.4) | 1.00 (0.62, 1.63) | 0.99 | 38 (22.4) | 9 (19.6) | 1.63 (0.56, 4.72) | 0.37 | 62 (20.1) | 32 (20.6) | 0.90 (0.51, 1.59) | 0.72 |
| All EOC, postmenopausal | ||||||||||||
| Low/low | 318 (22.7) | 149 (25.4) | 1.00 (referent) | 118 (22.4) | 37 (25.7) | 1.00 (referent) | 200 (22.9) | 112 (25.3) | 1.00 (referent) | |||
| High/low | 377 (26.9) | 157 (26.7) | 0.90 (0.68, 1.19) | 0.45 | 127 (24.1) | 35 (24.3) | 0.97 (0.57, 1.66) | 0.92 | 250 (28.6) | 122 (27.5) | 0.87 (0.63, 1.21) | 0.41 |
| Low/high | 357 (25.5) | 124 (21.1) | 0.77 (0.58, 1.02) | 0.06 | 152 (28.9) | 28 (19.4) | 0.61 (0.35, 1.06) | 0.08 | 205 (23.4) | 96 (21.7) | 0.84 (0.61, 1.17) | 0.30 |
| High/high | 349 (24.9) | 157 (26.7) | 0.98 (0.75, 1.29) | 0.88 | 129 (24.5) | 44 (30.6) | 1.13 (0.66, 1.91) | 0.66 | 220 (25.1) | 113 (25.5) | 0.93 (0.67, 1.27) | 0.63 |
| Serous cases | ||||||||||||
| Low/low | 249 (23.6) | 124 (28.0) | 1.00 (referent) | 100 (25.3) | 23 (21.3) | 1.00 (referent) | 149 (22.5) | 101 (30.1) | 1.00 (referent) | |||
| High/low | 257 (24.3) | 108 (24.4) | 0.83 (0.60, 1.15) | 0.27 | 88 (22.2) | 33 (30.6) | 1.66 (0.90, 3.07) | 0.11 | 169 (25.6) | 75 (22.4) | 0.64 (0.43, 0.93) | 0.02 |
| Low/high | 288 (27.2) | 113 (25.5) | 0.80 (0.59, 1.09) | 0.16 | 108 (27.3) | 32 (29.6) | 1.30 (0.71, 2.39) | 0.39 | 180 (27.2) | 81 (24.2) | 0.67 (0.47, 0.96) | 0.03 |
| High/higha | 263 (24.9) | 98 (22.1) | 0.75 (0.54, 1.03) | 0.08 | 100 (25.3) | 20 (18.5) | 0.85 (0.43, 1.68) | 0.64 | 163 (24.7) | 78 (23.3) | 0.71 (0.49, 1.03) | 0.07 |
| Mucinous cases | ||||||||||||
| Low/low | 38 (25.5) | 14 (24.1) | 1.00 (referent) | 11 (15.7) | 5 (27.8) | 1.00 (referent) | 27 (34.2) | 9 (22.5) | 1.00 (referent) | |||
| High/low | 46 (30.9) | 18 (31.0) | 1.25 (0.54, 2.90) | 0.61 | 25 (35.7) | 7 (38.9) | 0.53 (0.12, 2.32) | 0.40 | 21 (26.6) | 11 (27.5) | 1.53 (0.54, 4.37) | 0.42 |
| Low/high | 34 (22.8) | 9 (15.5) | 0.78 (0.30, 2.03) | 0.61 | 16 (22.9) | 2 (11.1) | 0.26 (0.04, 1.66) | 0.15 | 18 (22.8) | 7 (17.5) | 1.12 (0.35, 3.63) | 0.84 |
| High/higha | 31 (20.8) | 17 (29.3) | 1.64 (0.69, 3.92) | 0.26 | 18 (25.7) | 4 (22.2) | 0.43 (0.09, 2.06) | 0.29 | 13 (16.5) | 13 (32.5) | 3.00 (0.99, 9.08) | 0.05 |
| Endometrioid cases | ||||||||||||
| Low/low | 62 (27.2) | 18 (18.9) | 1.00 (referent) | 20 (22.7) | 6 (25.0) | 1.00 (referent) | 42 (30.0) | 12 (16.9) | 1.00 (referent) | |||
| High/low | 56 (24.6) | 26 (27.4) | 1.66 (0.82, 3.37) | 0.16 | 23 (26.1) | 3 (12.5) | 0.49 (0.10, 2.28) | 0.36 | 33 (23.6) | 23 (32.4) | 2.42 (1.04, 5.62) | 0.04 |
| Low/high | 64 (28.1) | 24 (25.3) | 1.41 (0.69, 2.86) | 0.35 | 27 (30.7) | 4 (16.7) | 0.51 (0.12, 2.20) | 0.37 | 37 (26.4) | 20 (28.2) | 1.91 (0.83, 4.41) | 0.13 |
| High/higha | 46 (20.2) | 27 (28.4) | 2.22 (1.06, 4.68) | 0.04 | 18 (20.5) | 11 (45.8) | 1.96 (0.59, 6.58) | 0.27 | 28 (20.0) | 16 (22.5) | 2.03 (0.80, 5.17) | 0.14 |
| CA125 / anti-CA125 antibodies | ||||||||||||
| All EOC | ||||||||||||
| Low/low | 481 (25.0) | 196 (24.3) | 1.00 (referent) | 174 (24.4) | 31 (16.0) | 1.00 (referent) | 307 (25.3) | 165 (27.0) | 1.00 (referent) | |||
| High/low | 479 (24.9) | 241 (29.9) | 1.30 (1.03, 1.64) | 0.03 | 164 (23.0) | 71 (36.6) | 2.67 (1.63, 4.35) | <0.0001 | 315 (26.0) | 170 (27.8) | 1.02 (0.78, 1.34) | 0.88 |
| Low/high | 483 (25.1) | 138 (17.1) | 0.71 (0.55, 0.91) | 0.01 | 192 (26.9) | 18 (9.3) | 0.54 (0.29, 1.01) | 0.05 | 291 (24.0) | 120 (19.6) | 0.75 (0.56, 1.00) | 0.05 |
| High/high | 483 (25.1) | 231 (28.7) | 1.26 (0.99, 1.60) | 0.06 | 183 (25.7) | 74 (38.1) | 2.48 (1.53, 4.00) | 0.0002 | 300 (24.7) | 157 (25.7) | 0.98 (0.74, 1.30) | 0.91 |
| All EOC, premenopausal | ||||||||||||
| Low/low | 80 (16.7) | 34 (16.9) | 1.00 (referent) | 30 (17.5) | 9 (19.6) | 1.00 (referent) | 50 (16.2) | 25 (16.1) | 1.00 (referent) | |||
| High/low | 165 (34.4) | 75 (37.3) | 1.07 (0.65, 1.78) | 0.79 | 59 (34.5) | 15 (32.6) | 0.91 (0.35, 2.36) | 0.84 | 106 (34.3) | 60 (38.7) | 1.16 (0.64, 2.10) | 0.64 |
| Low/high | 73 (15.2) | 21 (10.4) | 0.65 (0.34, 1.25) | 0.20 | 25 (14.6) | 2 (4.3) | 0.26 (0.05, 1.37) | 0.11 | 48 (15.5) | 19 (12.3) | 0.78 (0.38, 1.63) | 0.51 |
| High/high | 162 (33.8) | 71 (35.3) | 1.07 (0.64, 1.77) | 0.81 | 57 (33.3) | 20 (43.5) | 1.33 (0.53, 3.33) | 0.54 | 105 (34.0) | 51 (32.9) | 0.98 (0.53, 1.80) | 0.95 |
| All EOC, postmenopausal | ||||||||||||
| Low/low | 393 (27.9) | 158 (26.8) | 1.00 (referent) | 143 (27.0) | 22 (15.2) | 1.00 (referent) | 250 (28.5) | 136 (30.6) | 1.00 (referent) | |||
| High/low | 305 (21.7) | 163 (27.7) | 1.38 (1.06, 1.81) | 0.02 | 102 (19.3) | 54 (37.2) | 3.69 (2.06, 6.60) | <0.0001 | 203 (23.1) | 109 (24.5) | 1.00 (0.73, 1.36) | 0.99 |
| Low/high | 405 (28.8) | 115 (19.5) | 0.71 (0.54, 0.95) | 0.02 | 166 (31.4) | 16 (11.0) | 0.66 (0.34, 1.31) | 0.24 | 239 (27.2) | 99 (22.3) | 0.75 (0.54, 1.02) | 0.07 |
| High/high | 304 (21.6) | 153 (26.0) | 1.32 (1.00, 1.74) | 0.05 | 118 (22.3) | 53 (36.6) | 2.95 (1.67, 5.20) | 0.0002 | 186 (21.2) | 100 (22.5) | 0.99 (0.71, 1.37) | 0.95 |
| Serous cases | ||||||||||||
| Low/low | 247 (23.3) | 108 (24.4) | 1.00 (referent) | 104 (26.2) | 14 (13.0) | 1.00 (referent) | 143 (21.5) | 94 (28.1) | 1.00 (referent) | |||
| High/low | 276 (26.0) | 137 (30.9) | 1.16 (0.85, 1.58) | 0.35 | 91 (22.9) | 41 (38.0) | 3.91 (1.92, 7.96) | 0.0002 | 185 (27.9) | 96 (28.7) | 0.80 (0.55, 1.15) | 0.22 |
| Low/high | 260 (24.5) | 73 (16.5) | 0.64 (0.45, 0.91) | 0.01 | 106 (26.7) | 12 (11.1) | 0.84 (0.37, 1.89) | 0.68 | 154 (23.2) | 61 (18.2) | 0.60 (0.40, 0.89) | 0.01 |
| High/highb | 278 (26.2) | 125 (28.2) | 1.07 (0.77, 1.46) | 0.70 | 96 (24.2) | 41 (38.0) | 3.51 (1.76, 7.02) | 0.0004 | 182 (27.4) | 84 (25.1) | 0.71 (0.49, 1.03) | 0.07 |
| Mucinous cases | ||||||||||||
| Low/low | 36 (24.2) | 11 (19.0) | 1.00 (referent) | 12 (17.1) | 6 (33.3) | 1.00 (referent) | 24 (30.4) | 5 (12.5) | 1.00 (referent) | |||
| High/low | 43 (28.9) | 16 (27.6) | 1.37 (0.51, 3.68) | 0.53 | 22 (31.4) | 3 (16.7) | 0.22 (0.04, 1.20) | 0.08 | 21 (26.6) | 13 (32.5) | 3.80 (1.00, 14.46) | 0.05 |
| Low/high | 33 (22.1) | 9 (15.5) | 0.97 (0.35, 2.70) | 0.95 | 15 (21.4) | 1 (5.6) | 0.12 (0.01, 1.17) | 0.07 | 18 (22.8) | 8 (20.0) | 2.57 (0.68, 9.66) | 0.16 |
| High/highb | 37 (24.8) | 22 (37.9) | 2.34 (0.91, 6.03) | 0.08 | 21 (30.0) | 8 (44.4) | 0.65 (0.16, 2.56) | 0.54 | 16 (20.3) | 14 (35.0) | 5.45 (1.42, 20.98) | 0.01 |
| Endometrioid cases | ||||||||||||
| Low/low | 65 (28.4) | 21 (21.9) | 1.00 (referent) | 24 (27.0) | 3 (12.0) | 1.00 (referent) | 41 (29.3) | 18 (25.4) | 1.00 (referent) | |||
| High/low | 55 (24.0) | 29 (30.2) | 1.78 (0.89, 3.54) | 0.10 | 18 (20.2) | 9 (36.0) | 3.67 (0.91, 14.82) | 0.07 | 37 (26.4) | 20 (28.2) | 1.29 (0.58, 2.91) | 0.53 |
| Low/high | 59 (25.8) | 20 (20.8) | 1.10 (0.53, 2.30) | 0.80 | 28 (31.5) | 4 (16.0) | 1.04 (0.21, 5.25) | 0.96 | 31 (22.1) | 16 (22.5) | 1.21 (0.52, 2.82) | 0.66 |
| High/highb | 50 (21.8) | 26 (27.1) | 1.87 (0.90, 3.87) | 0.09 | 19 (21.3) | 9 (36.0) | 4.06 (0.92, 17.86) | 0.06 | 31 (22.1) | 17 (23.9) | 1.33 (0.57, 3.13) | 0.51 |
a
p-heterogeneity for high/high vs. low/low across serous, mucinous and endometrioid histologic types: all, p=0.01; <3 years, p=0.29; ≥3 years, p=0.01.
b
p-heterogeneity for high/high vs. low/low across serous, mucinous and endometrioid histologic types: all, p=0.15; <3 years, p=0.08; ≥3 years, p=0.01.