Table 2-A:
Baseline Characteristics of Population of PAH Patients - PLS stratification
| Characteristic | PLS≤25 [N=33] |
PLS>25 [N=30] |
Total [N= 63] |
P-value |
|---|---|---|---|---|
| Age (yrs.) | 0.788 | |||
| N | 33 | 30 | 63 | |
| Mean (S.D.) | 58.4 (11.54) | 57.8 (13.66) | 58.1 (12.49) | |
| Median (Q1, Q3) | 61.0 (50.0, 66.0) | 57.0 (46.0, 68.0) | 59.0 (48.0, 66.0) | |
| (Min., Max.) | (41, 80) | (35, 84) | (35, 84) | |
| Sex | 0.094 | |||
| Male | 1/33 (3.0%) | 5/30 (16.7%) | 6/63 (9.5%) | |
| Female | 32/33 (97.0%) | 25/30 (83.3%) | 57/63 (90.5%) | |
| Race | 0.872 | |||
| White | 24/32 (75.0%) | 20/28 (71.4%) | 44/60 (73.3%) | |
| Black | 7/32 (21.9%) | 7/28 (25.0%) | 14/60 (23.3%) | |
| Asian | 0/32 (0.0%) | 1/28 (3.6%) | 1/60 (1.7%) | |
| Other | 1/32 (3.1%) | 0/28 (0.0%) | 1/60 (1.7%) | |
| WHO Functional Class | 0.147 | |||
| 1 | 1/33 (3.0%) | 0/30 (0.0%) | 1/63 (1.6%) | |
| 2 | 16/33 (48.5%) | 22/30 (73.3%) | 38/63 (60.3%) | |
| 3 | 12/33 (36.4%) | 7/30 (23.3%) | 19/63 (30.2%) | |
| 4 | 4/33 (12.1%) | 1/30 (3.3%) | 5/63 (7.9%) | |
| Six-min. Walk Distance (m) | 0.313 | |||
| N | 31 | 30 | 61 | |
| Mean (S.D.) | 349.5 (149.55) | 394.3 (108.76) | 371.5 (131.95) | |
| Median (Q1, Q3) | 376.7 (236.0, 493.8) | 408.5 (302.7, 477.4) | 407.0 (263.0, 480.0) | |
| (Min., Max.) | (73.0, 575.0) | (152.0, 582.5) | (73.0, 582.5) | |
| PH Medications | 1.000 | |||
| 0 | 4/33 (12.1%) | 4/30 (13.3%) | 8/63 (12.7%) | |
| 1 | 29/33 (87.9%) | 26/30 (86.7%) | 55/63 (87.3%) | |
| RA Mean | 0.290 | |||
| N | 32 | 29 | 61 | |
| Mean (S.D.) | 10.9 (11.52) | 7.8 (3.79) | 9.4 (8.82) | |
| Median (Q1, Q3) | 8.5 (5.5, 13.0) | 7.0 (5.0, 9.0) | 8.0 (5.0, 11.0) | |
| (Min., Max.) | (1, 68) | (2, 17) | (1, 68) | |
| PA Mean | 0.725 | |||
| N | 33 | 30 | 63 | |
| Mean (S.D.) | 47.5 (14.96) | 47.0 (12.09) | 47.3 (13.56) | |
| Median (Q1, Q3) | 51.0 (38.0, 54.0) | 46.5 (40.0, 54.0) | 47.0 (40.0, 54.0) | |
| (Min., Max.) | (20, 80) | (27, 72) | (20, 80) | |
| PA systolic | 0.761 | |||
| N | 33 | 29 | 62 | |
| Mean (S.D.) | 73.3 (21.46) | 75.4 (18.54) | 74.3 (20.02) | |
| Median (Q1, Q3) | 75.0 (60.0, 86.0) | 74.0 (66.0, 90.0) | 75.0 (60.0, 90.0) | |
| (Min., Max.) | (35, 118) | (42, 110) | (35, 118) | |
| PA diastolic | 0.525 | |||
| N | 33 | 29 | 62 | |
| Mean (S.D.) | 31.5 (11.33) | 29.7 (9.67) | 30.6 (10.54) | |
| Median (Q1, Q3) | 32.0 (23.0, 39.0) | 31.0 (22.0, 35.0) | 31.5 (22.0, 38.0) | |
| (Min., Max.) | (10, 54) | (12, 48) | (10, 54) | |
| Cardiac Index (L/min/m2) | 0.923 | |||
| N | 33 | 30 | 63 | |
| Mean (S.D.) | 2.5 (0.81) | 2.6 (0.83) | 2.5 (0.81) | |
| Median (Q1, Q3) | 2.2 (2.1, 3.0) | 2.5 (1.8, 3.1) | 2.3 (1.9, 3.0) | |
| (Min., Max.) | (1.4, 4.8) | (1.5, 4.6) | (1.4, 4.8) | |
| PVR (WU) | 0.907 | |||
| N | 33 | 30 | 63 | |
| Mean (S.D.) | 10.0 (5.56) | 9.9 (5.42) | 10.0 (5.45) | |
| Median (Q1, Q3) | 9.9 (5.6, 13.3) | 8.7 (6.4, 13.9) | 9.6 (5.8, 13.4) | |
| (Min., Max.) | (1.6, 27.1) | (1.5, 20.3) | (1.5, 27.1) | |
| Reveal Risk Score | 0.013 | |||
| N | 33 | 30 | 63 | |
| Mean (S.D.) | 7.8 (3.20) | 5.8 (2.46) | 6.9 (3.03) | |
| Median (Q1, Q3) | 8.0 (5.0, 10.0) | 6.0 (4.0, 7.0) | 6.0 (5.0, 9.0) | |
| (Min., Max.) | (3, 14) | (2, 11) | (2, 14) |
PLS= Peak longitudinal strain, PH= Pulmonary Hypertension, WHO= World Health Organization