Table 2B:
Baseline Characteristics of Population of PAH Patients – PACS stratification
| Characteristic | PACS≤ 13 [N=34] |
PACS>13 [N=29] |
Total [N=63] |
P-value |
|---|---|---|---|---|
| Age (yrs.) | 0.473 | |||
| N | 34 | 29 | 63 | |
| Mean (S.D.) | 59.4 (13.15) | 56.7 (11.74) | 58.1 (12.49) | |
| Median (Q1, Q3) | 61.5 (46.0, 69.0) | 56.0 (48.0, 66.0) | 59.0 (48.0, 66.0) | |
| (Min., Max.) | (41, 84) | (35, 80) | (35, 84) | |
| Sex | 0.007 | |||
| Male | 0/34 (0.0%) | 6/29 (20.7%) | 6/63 (9.5%) | |
| Female | 34/34 (100.0%) | 23/29 (79.3%) | 57/63 (90.5%) | |
| Race | 0.855 | |||
| White | 25/34 (73.5%) | 19/26 (73.1%) | 44/60 (73.3%) | |
| Black | 8/34 (23.5%) | 6/26 (23.1%) | 14/60 (23.3%) | |
| Asian | 0/34 (0.0%) | 1/26 (3.8%) | 1/60 (1.7%) | |
| Other | 1/34 (2.9%) | 0/26 (0.0%) | 1/60 (1.7%) | |
| WHO Functional Class | 0.507 | |||
| 1 | 1/34 (2.9%) | 0/29 (0.0%) | 1/63 (1.6%) | |
| 2 | 20/34 (58.8%) | 18/29 (62.1%) | 38/63 (60.3%) | |
| 3 | 9/34 (26.5%) | 10/29 (34.5%) | 19/63 (30.2%) | |
| 4 | 4/34 (11.8%) | 1/29 (3.4%) | 5/63 (7.9%) | |
| PH Medications | 1.000 | |||
| 0 | 4/34 (11.8%) | 4/29 (13.8%) | 8/63 (12.7%) | |
| 1 | 30/34 (88.2%) | 25/29 (86.2%) | 55/63 (87.3%) | |
| Right Atrial Mean | 0.412 | |||
| N | 33 | 28 | 61 | |
| Mean (S.D.) | 8.4 (5.06) | 10.6 (11.83) | 9.4 (8.82) | |
| Median (Q1, Q3) | 6.0 (4.0, 11.0) | 8.0 (6.0, 11.0) | 8.0 (5.0, 11.0) | |
| (Min., Max.) | (1, 21) | (2, 68) | (1, 68) | |
| Pulmonary Artery Mean | 0.408 | |||
| N | 34 | 29 | 63 | |
| Mean (S.D.) | 45.4 (12.74) | 49.6 (14.35) | 47.3 (13.56) | |
| Median (Q1, Q3) | 47.5 (34.0, 52.0) | 47.0 (40.0, 60.0) | 47.0 (40.0, 54.0) | |
| (Min., Max.) | (20, 70) | (25, 80) | (20, 80) | |
| Pulmonary Arterial systolic | 0.369 | |||
| N | 34 | 28 | 62 | |
| Mean (S.D.) | 71.7 (18.76) | 77.5 (21.36) | 74.3 (20.02) | |
| Median (Q1, Q3) | 75.5 (56.0, 82.0) | 73.5 (62.5, 91.0) | 75.0 (60.0, 90.0) | |
| (Min., Max.) | (35, 102) | (42, 118) | (35, 118) | |
| Pulmonary Arterial diastolic | 0.420 | |||
| N | 34 | 28 | 62 | |
| Mean (S.D.) | 29.6 (10.14) | 31.9 (11.05) | 30.6 (10.54) | |
| Median (Q1, Q3) | 30.5 (20.0, 35.0) | 33.0 (23.0, 39.0) | 31.5 (22.0, 38.0) | |
| (Min., Max.) | (10, 50) | (12, 54) | (10, 54) | |
| Cardiac Index (L/min/m2) | 0.490 | |||
| N | 34 | 29 | 63 | |
| Mean (S.D.) | 2.5 (0.71) | 2.7 (0.92) | 2.5 (0.81) | |
| Median (Q1, Q3) | 2.3 (1.9, 2.9) | 2.6 (1.9, 3.1) | 2.3 (1.9, 3.0) | |
| (Min., Max.) | (1.4, 4.4) | (1.5, 4.8) | (1.4, 4.8) | |
| Pulmonary Vascular Resistance (WU) | 0.735 | |||
| N | 34 | 29 | 63 | |
| Mean (S.D.) | 9.5 (4.81) | 10.5 (6.16) | 10.0 (5.45) | |
| Median (Q1, Q3) | 9.6 (5.6, 13.3) | 9.6 (6.4, 13.6) | 9.6 (5.8, 13.4) | |
| (Min., Max.) | (1.6, 20.3) | (1.5, 27.1) | (1.5, 27.1) | |
| Reveal Risk Score | 0.961 | |||
| N | 34 | 29 | 63 | |
| Mean (S.D.) | 7.0 (3.47) | 6.7 (2.47) | 6.9 (3.03) | |
| Median (Q1, Q3) | 6.0 (4.0, 10.0) | 7.0 (5.0, 8.0) | 6.0 (5.0, 9.0) | |
| (Min., Max.) | (3, 14) | (2, 11) | (2, 14) |
PACS= Peak active contraction strain, PH= Pulmonary Hypertension, WHO= World Health Organization. Note: The median value of PACS is 12.5, (which is not technically the median, but a rounded up version of the median). There is 1 patient with 12.5, 1 patient with 12.8, and 1 patient with 13 for PACS.