Table 3A:
Baseline Echocardiographic Variables for the Study Population of PAH Patients - PLS stratification
| Echo Parameter | PLS≤25 [N=33] |
PLS>25 [N=30] |
Total [N= 63] |
P-value |
|---|---|---|---|---|
| LV Ejection Fraction (%) | 0.228 | |||
| N | 30 | 28 | 58 | |
| Mean (S.D.) | 59.91 (6.99) | 62.19 (6.89) | 61.01 (6.98) | |
| Median (Q1, Q3) | 59.54 (53.65, 67.15) | 60.97 (57.49, 68.10) | 60.32 (56.23, 67.27) | |
| (Min., Max.) | (44.95, 70.59) | (48.77, 74.59) | (44.95, 74.59) | |
| Tricuspid Valve Regurgitation | 0.303 | |||
| Trivial | 12/33 (36.4%) | 13/30 (43.3%) | 25/63 (39.7%) | |
| Mild | 8/33 (24.2%) | 11/30 (36.7%) | 19/63 (30.2%) | |
| Moderate | 8/33 (24.2%) | 5/30 (16.7%) | 13/63 (20.6%) | |
| Severe | 5/33 (15.2%) | 1/30 (3.3%) | 6/63 (9.5%) | |
| Right Atrial Area (cm2) | 0.033 | |||
| N | 33 | 30 | 63 | |
| Mean (S.D.) | 22.2 (6.71) | 19.1 (4.92) | 20.8 (6.08) | |
| Median (Q1, Q3) | 21.1 (18.2, 25.9) | 18.2 (15.9, 20.5) | 20.2 (16.3, 23.7) | |
| (Min., Max.) | (12.7, 40.7) | (11.5, 30.3) | (11.5, 40.7) | |
| Right Atrial Volume (ml) | 0.044 | |||
| N | 32 | 30 | 62 | |
| Mean (S.D.) | 75.3 (36.10) | 58.8 (24.22) | 67.3 (31.79) | |
| Median (Q1, Q3) | 68.1 (50.0, 87.6) | 53.2 (42.2, 68.5) | 61.6 (43.4, 74.7) | |
| (Min., Max.) | (28.8, 176.3) | (26.2, 110.6) | (26.2, 176.3) | |
| RV FAC (%) | 0.055 | |||
| N | 32 | 30 | 62 | |
| Mean (S.D.) | 30.4 (8.23) | 34.5 (8.21) | 32.4 (8.40) | |
| Median (Q1, Q3) | 28.2 (24.6, 37.1) | 35.0 (29.1, 41.9) | 32.5 (25.8, 39.1) | |
| (Min., Max.) | (18.3, 46.5) | (17.5, 50.4) | (17.5, 50.4) | |
| RV GLS (%) | <0.001 | |||
| N | 31 | 30 | 61 | |
| Mean (S.D.) | −16.3 (4.99) | −20.5 (4.64) | −18.4 (5.23) | |
| Median (Q1, Q3) | −15.7 (−18.2, −13.3) | −20.1 (−22.2, −18.6) | −18.3 (−21.2, −14.2) | |
| (Min., Max.) | (−33.1, −7.8) | (−32.1, −8.9) | (−33.1, −7.8) | |
| (Min., Max.) | (−27.3, −14.0) | (−30.5, −10.3) | (−30.5, −10.3) | |
| LV GLS (%) | 0.514 | |||
| N | 23 | 27 | 50 | |
| Mean (S.D.) | −19.1 (2.91) | −18.4 (3.49) | −18.7 (3.22) | |
| Median (Q1, Q3) | −19.0 (−21.5, −16.5) | −18.4 (−21.7, −15.8) | −18.5 (−21.5, −16.2) | |
| (Min., Max.) | (−25.5, −14.6) | (−25.8, −11.2) | (−25.8, −11.2) | |
| TAPSE (cm) | <0.001 | |||
| N | 32 | 30 | 62 | |
| Mean (S.D.) | 1.7 (0.41) | 2.1 (0.45) | 1.9 (0.47) | |
| Median (Q1, Q3) | 1.7 (1.5, 1.9) | 2.2 (1.8, 2.4) | 1.9 (1.6, 2.2) | |
| (Min., Max.) | (0.9, 2.7) | (1.0, 2.8) | (0.9, 2.8) | |
| PLS % | <0.001 | |||
| N | 33 | 30 | 63 | |
| Mean (S.D.) | 17.26 (7.22) | 34.62 (7.54) | 25.53 (11.40) | |
| Median (Q1, Q3) | 19.80 (15.00, 23.00) | 34.00 (28.00, 40.10) | 25.00 (18.50, 34.00) | |
| (Min., Max.) | (0.02, 25.00) | (25.20, 52.00) | (0.02, 52.00) | |
| Time to PLS | 0.407 | |||
| N | 31 | 30 | 61 | |
| Mean (S.D.) | 384 (94) | 408 (78) | 396 (87) | |
| Median (Q1, Q3) | 389 (320, 430) | 398 (360, 431) | 395 (350, 430) | |
| (Min., Max.) | (200, 567) | (291, 620) | (200, 620) | |
| PACS % | <0.001 | |||
| N | 33 | 30 | 63 | |
| Mean (S.D.) | 10.19 (5.31) | 17.70 (6.07) | 13.77 (6.79) | |
| Median (Q1, Q3) | 10.00 (8.10, 11.90) | 15.85 (13.00, 21.30) | 12.50 (9.70, 16.30) | |
| (Min., Max.) | (0.01, 26.00) | (9.20, 31.00) | (0.01, 31.00) | |
| Time to PACS | 0.278 | |||
| N | 29 | 30 | 59 | |
| Mean (S.D.) | 693 (189) | 721 (167) | 707 (177) | |
| Median (Q1, Q3) | 635 (559, 774) | 687 (632, 790) | 675 (596, 783) | |
| (Min., Max.) | (446, 1333) | (478, 1334) | (446, 1334) | |
| PSSR | <0.001 | |||
| N | 31 | 30 | 61 | |
| Mean (S.D.) | 1.05 (0.31) | 1.35 (0.33) | 1.20 (0.35) | |
| Median (Q1, Q3) | 1.00 (0.90, 1.30) | 1.20 (1.10, 1.50) | 1.10 (1.00, 1.40) | |
| (Min., Max.) | (0.40, 1.70) | (1.00, 2.10) | (0.40, 2.10) | |
| Time to PSSR | 0.392 | |||
| N | 28 | 30 | 58 | |
| Mean (S.D.) | 174 (70) | 179 (40) | 177 (56) | |
| Median (Q1, Q3) | 176 (126, 196) | 172 (150, 206) | 175 (145, 200) | |
| (Min., Max.) | (76, 400) | (85, 261) | (76, 400) | |
| PEDSR | 0.003 | |||
| N | 24 | 25 | 49 | |
| Mean (S.D.) | 0.44 (0.34) | 0.74 (0.41) | 0.59 (0.40) | |
| Median (Q1, Q3) | 0.36 (0.30, 0.54) | 0.69 (0.42, 0.95) | 0.49 (0.34, 0.80) | |
| (Min., Max.) | (0.06, 1.70) | (0.04, 1.78) | (0.04, 1.78) | |
| Time to PEDSR | 0.112 | |||
| N | 18 | 22 | 40 | |
| Mean (S.D.) | 672 (143) | 762 (187) | 722 (173) | |
| Median (Q1, Q3) | 668 (557, 764) | 743 (659, 776) | 697 (600, 773) | |
| (Min., Max.) | (471, 922) | (500, 1379) | (471, 1379) | |
| PCSR | 0.010 | |||
| N | 22 | 22 | 44 | |
| Mean (S.D.) | 1.03 (0.55) | 1.52 (0.62) | 1.27 (0.63) | |
| Median (Q1, Q3) | 0.82 (0.58, 1.30) | 1.55 (1.10, 2.00) | 1.21 (0.74, 1.70) | |
| (Min., Max.) | (0.38, 2.30) | (0.54, 2.80) | (0.38, 2.80) | |
| Time to PCSR | 0.288 | |||
| N | 20 | 25 | 45 | |
| Mean (S.D.) | 483 (115) | 520 (109) | 504 (112) | |
| Median (Q1, Q3) | 526 (362, 561) | 533 (450, 590) | 533 (427, 581) | |
| (Min., Max.) | (277, 643) | (299, 700) | (277, 700) |
LV= Left ventricle, RV= Right ventricle, FAC= Fractional area change, GLS= Global longitudinal strain, TAPSE= Tricuspid annular plane systolic excursion, PLS= Peak longitudinal strain, PACS= Peak active contraction strain, PSSR= Peak systolic strain rate, PEDSR= Peak diastolic strain rate, PCSR= Peak contraction strain rate.