Table 3B:
Baseline Echocardiographic Variables for the Study Population of PAH Patients - PACS stratification
| Echo Parameter | PACS≤13 [N=34] |
PACS>13 [N= 29] |
Total [N= 63] |
P-value |
|---|---|---|---|---|
| LV Ejection Fraction (%) | 0.690 | |||
| N | 32 | 26 | 58 | |
| Mean (S.D.) | 60.80 (6.50) | 61.26 (7.64) | 61.01 (6.98) | |
| Median (Q1, Q3) | 60.32 (55.59, 67.21) | 60.63 (56.50, 68.73) | 60.32 (56.23, 67.27) | |
| (Min., Max.) | (50.32, 74.23) | (44.95, 74.59) | (44.95, 74.59) | |
| Tricuspid Valve Regurgitation | 0.807 | |||
| Trivial | 13/34 (38.2%) | 12/29 (41.4%) | 25/63 (39.7%) | |
| Mild | 9/34 (26.5%) | 10/29 (34.5%) | 19/63 (30.2%) | |
| Moderate | 8/34 (23.5%) | 5/29 (17.2%) | 13/63 (20.6%) | |
| Severe | 4/34 (11.8%) | 2/29 (6.9%) | 6/63 (9.5%) | |
| RA Area (cm2) | 0.159 | |||
| N | 34 | 29 | 63 | |
| Mean (S.D.) | 22.0 (7.15) | 19.3 (4.20) | 20.8 (6.08) | |
| Median (Q1, Q3) | 21.0 (15.7, 26.7) | 18.6 (16.7, 21.1) | 20.2 (16.3, 23.7) | |
| (Min., Max.) | (11.5, 40.7) | (12.9, 30.3) | (11.5, 40.7) | |
| RA Volume (ml) | 0.233 | |||
| N | 33 | 29 | 62 | |
| Mean (S.D.) | 73.8 (38.37) | 59.9 (20.28) | 67.3 (31.79) | |
| Median (Q1, Q3) | 63.0 (43.4, 100.1) | 58.2 (45.5, 68.5) | 61.6 (43.4, 74.7) | |
| (Min., Max.) | (26.2, 176.3) | (31.5, 110.6) | (26.2, 176.3) | |
| RV FAC (%) | 0.708 | |||
| N | 33 | 29 | 62 | |
| Mean (S.D.) | 31.9 (8.39) | 32.9 (8.54) | 32.4 (8.40) | |
| Median (Q1, Q3) | 30.1 (25.7, 38.8) | 33.2 (26.3, 39.1) | 32.5 (25.8, 39.1) | |
| (Min., Max.) | (18.3, 46.5) | (17.5, 50.4) | (17.5, 50.4) | |
| RV GLS (%) | 0.151 | |||
| N | 32 | 29 | 61 | |
| Mean (S.D.) | −17.7 (5.72) | −19.2 (4.59) | −18.4 (5.23) | |
| Median (Q1, Q3) | −18.0 (−20.1, −13.6) | −18.7 (−21.7, −16.1) | −18.3 (−21.2, −14.2) | |
| (Min., Max.) | (−33.1, −7.8) | (−31.5, −8.9) | (−33.1, −7.8) | |
| LV GLS (%) | 0.372 | |||
| N | 24 | 26 | 50 | |
| Mean (S.D.) | −19.1 (2.95) | −18.3 (3.46) | −18.7 (3.22) | |
| Median (Q1, Q3) | −18.8 (−21.9, −16.8) | −18.4 (−21.0, −15.9) | −18.5 (−21.5, −16.2) | |
| (Min., Max.) | (−25.5, −14.6) | (−25.8, −11.2) | (−25.8, −11.2) | |
| TAPSE (cm) | 0.003 | |||
| N | 34 | 28 | 62 | |
| Mean (S.D.) | 1.8 (0.43) | 2.1 (0.45) | 1.9 (0.47) | |
| Median (Q1, Q3) | 1.7 (1.6, 2.0) | 2.2 (1.8, 2.4) | 1.9 (1.6, 2.2) | |
| (Min., Max.) | (0.9, 2.8) | (1.0, 2.8) | (0.9, 2.8) | |
| PLS | <.001 | |||
| N | 34 | 29 | 63 | |
| Mean (S.D.) | 19.74 (9.67) | 32.31 (9.44) | 25.53 (11.40) | |
| Median (Q1, Q3) | 20.50 (15.00, 25.00) | 30.10 (25.20, 40.10) | 25.00 (18.50, 34.00) | |
| (Min., Max.) | (0.02, 38.00) | (15.00, 52.00) | (0.02, 52.00) | |
| Time to PLS | 0.897 | |||
| N | 32 | 29 | 61 | |
| Mean (S.D.) | 393.16 (86.93) | 398.62 (87.45) | 395.75 (86.49) | |
| Median (Q1, Q3) | 395.00 (351.50, 430.00) | 390.00 (347.00, 431.00) | 395.00 (350.00, 430.00) | |
| (Min., Max.) | (200.00, 567.00) | (229.00, 620.00) | (200.00, 620.00) | |
| PACS | <0.001 | |||
| N | 34 | 29 | 63 | |
| Mean (S.D.) | 8.93 (3.25) | 19.43 (5.29) | 13.77 (6.79) | |
| Median (Q1, Q3) | 10.00 (8.10, 11.00) | 17.00 (15.30, 24.00) | 12.50 (9.70, 16.30) | |
| (Min., Max.) | (0.01, 13.00) | (13.50, 31.00) | (0.01, 31.00) | |
| Time to PACS | 0.559 | |||
| N | 30 | 29 | 59 | |
| Mean (S.D.) | 720.77 (184.78) | 693.62 (170.55) | 707.42 (176.92) | |
| Median (Q1, Q3) | 715.00 (605.00, 827.00) | 660.00 (596.00, 774.00) | 675.00 (596.00, 783.00) | |
| (Min., Max.) | (446.00, 1334.0) | (478.00, 1333.0) | (446.00, 1334.0) | |
| PSSR | 0.109 | |||
| N | 32 | 29 | 61 | |
| Mean (S.D.) | 1.11 (0.31) | 1.29 (0.37) | 1.20 (0.35) | |
| Median (Q1, Q3) | 1.10 (0.97, 1.30) | 1.20 (1.00, 1.50) | 1.10 (1.00, 1.40) | |
| (Min., Max.) | (0.40, 1.70) | (0.70, 2.10) | (0.40, 2.10) | |
| Time to PSSR | 0.539 | |||
| N | 29 | 29 | 58 | |
| Mean (S.D.) | 182.72 (63.30) | 170.93 (49.07) | 176.83 (56.45) | |
| Median (Q1, Q3) | 177.00 (150.00, 200.00) | 169.00 (145.00, 193.00) | 174.50 (145.00, 200.00) | |
| (Min., Max.) | (82.00, 400.00) | (76.00, 298.00) | (76.00, 400.00) | |
| PEDSR | 0.191 | |||
| N | 27 | 22 | 49 | |
| Mean (S.D.) | 0.54 (0.39) | 0.66 (0.41) | 0.59 (0.40) | |
| Median (Q1, Q3) | 0.41 (0.33, 0.65) | 0.60 (0.34, 0.86) | 0.49 (0.34, 0.80) | |
| (Min., Max.) | (0.06, 1.70) | (0.04, 1.78) | (0.04, 1.78) | |
| Time to PEDSR | 0.724 | |||
| N | 18 | 22 | 40 | |
| Mean (S.D.) | 746.22 (217.55) | 701.27 (127.72) | 721.50 (172.99) | |
| Median (Q1, Q3) | 717.50 (654.00, 872.00) | 696.50 (597.00, 769.00) | 696.50 (599.50, 773.00) | |
| (Min., Max.) | (471.00, 1379.0) | (500.00, 1058.0) | (471.00, 1379.0) | |
| PCSR | <0.001 | |||
| N | 22 | 22 | 44 | |
| Mean (S.D.) | 0.90 (0.42) | 1.64 (0.58) | 1.27 (0.63) | |
| Median (Q1, Q3) | 0.78 (0.58, 1.20) | 1.60 (1.27, 2.00) | 1.21 (0.74, 1.70) | |
| (Min., Max.) | (0.38, 2.00) | (0.52, 2.80) | (0.38, 2.80) | |
| Time to PCSR | 0.318 | |||
| N | 23 | 22 | 45 | |
| Mean (S.D.) | 517.83 (118.09) | 488.86 (106.28) | 503.67 (112.15) | |
| Median (Q1, Q3) | 550.00 (458.00, 602.00) | 496.50 (413.00, 564.00) | 533.00 (427.00, 581.00) | |
| (Min., Max.) | (277.00, 700.00) | (299.00, 700.00) | (277.00, 700.00) |
LV= Left ventricle, RV= Right ventricle, FAC= Fractional area change, GLS= Global longitudinal strain, TAPSE= Tricuspid annular plane systolic excursion, PLS= Peak longitudinal strain, PACS= Peak active contraction strain, PSSR= Peak systolic strain rate, PEDSR= Peak diastolic strain rate, PCSR= Peak contraction strain rate. Note: The median value of PACS is 12.5, (which is not technically the median, but a rounded up version of the median). There is 1 patient with 12.5, 1 patient with 12.8, and 1 patient with 13 for PACS.