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. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: Lab Invest. 2018 Jun 26;99(3):319–330. doi: 10.1038/s41374-018-0030-y

Figure 4. Non-heme iron deposition in Stage 2 CCM lesions in acute and chronic models.

Figure 4

(A) Lesions from chronic Krit1+/−Msh2−/− (16 lesions from 13 mice) harbor significantly higher (p=0.03) integrated density of non-heme iron deposition per lesional area compared to lesions from acute Cdh5iCreERT2Krit1ECKO (12 lesions from 9 mice). (B) Representative non-heme iron deposition (Perls blue stain) in Stage 2 lesions from an acute Cdh5iCreERT2Krit1ECKO model (upper) and a chronic Cdh5iCreERT2Krit1ECKO model (lower). Scale bars are 200 μm. All p values were considered to be statistically significant at *p<0.05.