Skip to main content
. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: Lab Invest. 2018 Jun 26;99(3):319–330. doi: 10.1038/s41374-018-0030-y

Figure 5. Inflammatory cells in Stage 2 lesions in acute and chronic CCM models.

Figure 5

(A) (Left) Chronic Krit1+/−Msh2−/−lesions (9 lesions from 9 mice) showed a significantly higher (p=0.005) number of B cells per lesional area than the Cdh5iCreERT2Krit1ECKO acute lesions (14 lesions from 5 mice). (Right) Representative image of a Stage 2 showing brown stained CD45R/B220 B cells in a chronic Krit1+/−Msh2−/− Stage 2 lesion. (B) (Left) Chronic Krit1+/−Msh2−/− lesions (9 lesions from 9 mice) showed a significantly higher (p=0.04) number of T cells per lesional area than the Cdh5iCreERT2Krit1ECKO acute lesions (14 lesions from 5 mice). (Right) Representative image of a Stage 2 showing staining of CD3 positive T cells in a chronic Krit1+/−Msh2−/− Stage 2 lesion. Scale bars are 50 μm. All p values were considered to be statistically significant at *p<0.05 or **p<0.01.