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Proposed functions of CST during telomere replication. (A) Telomerase is recruited by TPP1 for telomere extension. After G-overhang extension, CST is recruited to the telomere by TPP1. This leads to telomerase inhibition followed by polymerase alpha-mediated C-strand fill-in synthesis. (B) CST promotes telomere duplex replication by preventing or removing G-quadruplexes (G4s) and/or the recruitment of pol alpha for replication restart.
