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Clonal Hematopoiesis, as explained in the text, arises from somatic mutations in bone marrow stem cells, associated with ageing, that confer a proliferative advantage on the mutant clone. Mutations in Tet2 and in DNMT3A likely augment expression of pro-inflammatory genes by epigenetic regulation. Jak2 mutation can enhance NET formation, implicated in thrombosis, among other effects shown in B. Modified from reference 4.(Illustration Credit: Ben Smith).
