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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: Sci Transl Med. 2014 Jun 25;6(242):242ra84. doi: 10.1126/scitranslmed.3008455

Figure 7. Dual adjuvant therapy blocks pre-established breast cancer metastasis.

Figure 7.

(A) Bioluminescent imaging of 4T1-luc metastasis in vivo 50 days after mammary fat pad injection and 27 days after primary tumor resection. Treatments were initiated at the time of tumor resection.

(B) Quantification of tumor burden shown in (A) applying a maximum luminescence threshold of 5×107. Data represent mean ± SEM.

(C) Body weights were monitored for 20 days after tumor resection. Data represent mean ± SD.

(D) Kaplan-Meier survival curves were used to asses the impact of celecoxib and axitinib treatment on overall survival of the mice in (A-C). Log-rank analysis: p=0.007 combination vs. control, p=0.003 combination vs. axitinib, celecoxib vs. control was nonsignificant.