Table II.
Presence of EGFR mutation/polymorphisms in malignant peritoneal mesothelioma cells and sensitivity to erlotinib.
| Peritoneal mesothelioma cells | c.2062–104C→A (Intronic change) | c.2284–60T→C (Intronic change) | Q787Q (c.2607 G→A) (Exon 20) | T903T (c.2709 T→C) (Exon 23) | Sensitivity of peritoneal mesothelioma cells to erlotinib (IC50) |
|---|---|---|---|---|---|
| Early passage cells (n=8) | |||||
| NCI-M-03 | Wt | Wt | Hz | Wt | ND |
| NCI-M-05 | Wt | Wt | Hz | Hz | >50 μM |
| NCI-M-07 | Hz | Wt | Hm | Wt | >100 μM |
| NCI-M-09 | Wt | Wt | Hz | Hz | 10 μM |
| NCI-M-10 | Wt | Hz | Hz | Wt | 20 μM |
| NCI-M-11 | Hz | Hz | Hm | Wt | ND |
| NCI-M-14 | Wt | Wt | Hz | Wt | >50 μM |
| NCI-M-17 | Wt | Hz | Hm | Wt | >50 μM |
| Established cell lines (n=6) | |||||
| ORT | Wt | Wt | Hz | Wt | 10 μM |
| ROB | Wt | Wt | Hz | Wt | 10 μM |
| YOU | Wt | Hz | Hz | Wt | 40 μM |
| PET | Wt | Hz | Hm | Wt | >50 μM |
| HAY | Wt | Hz | Hm | Wt | >100 μM |
| HEC | Wt | Hz | Hm | Wt | >50 μM |
ND, not done; Wt, wild-type; Hz, heterozygous; Hm, homozygous.