Table 1.
Baseline characteristics stratified by quartiles of ICTP.
| ICTP Quartile |
||||
|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | |
| ICTP μg/L, range | 1.12–2.59 | 2.6 to 3.16 | 3.17 to 3.89 | 3.9–23.45 |
| Number of subjects | 803 | 819 | 805 | 817 |
| Demographics & anthropometries | ||||
| Age, years | 59 ± 9.3 | 62 ± 9.9 | 64 ± 10.2 | 67 ± 10.5 |
| Male sex | 374 (46.6) | 400 (48.8) | 423 (52.6) | 418 (51.2) |
| Race/ethnicity | ||||
| White | 252 (31.4) | 307 (37.5) | 322 (40.0) | 328 (40.2) |
| African American | 242 (30.1) | 230 (28.1) | 202 (25.1) | 225 (27.5) |
| Chinese American | 121 (15.1) | 94 (11.5) | 100 (12.4) | 69 (8.5) |
| Hispanic | 188 (23.4) | 188 (23.0) | 181 (22.5) | 195 (23.9) |
| Highest Education Level | ||||
| Less than high school | 145 (18.1) | 150 (18.3) | 157 (19.5) | 169 (20.7) |
| High school | 378 (47.2) | 387 (47.3) | 372 (46.3) | 378 (46.3) |
| Bachelor’s or greater | 278 (34.7) | 281 (34.4) | 275 (34.2) | 269 (33.0) |
| Height, cm | 165.7 ± 9.9 | 166.6 ± 10.3 | 166.8 ± 10.2 | 166.8 ± 10.3 |
| Weight, kg | 75.3 ± 15.8 | 77.2 ± 17.0 | 80.1 ± 16.7 | 83.1 ± 18.2 |
| Body mass index, kg/m2 | 27.3 ± 5.0 | 27.7 ± 5.1 | 28.6 ± 5.2 | 29.7 ± 5.9 |
| Body mass index category | ||||
| Underweight | 8 (1.0) | 13 (1.6) | 5 (0.6) | 6 (0.7) |
| Normal | 274 (34.1) | 243 (29.7) | 194 (24.1) | 154 (18.9) |
| Overweight | 327 (40.7) | 337 (41.2) | 323 (40.1) | 311 (38.1) |
| Obese Class I | 138 (17.2) | 157 (19.2) | 188 (23.4) | 215 (26.3) |
| Obese Class II/III | 56 (7.0) | 69 (8.4) | 95 (11.8) | 131 (16.0) |
| Waist circumference, cm | 94.9 ± 13.2 | 96.2 ± 13.3 | 100.1 ± 13.7 | 103.3 ± 15.4 |
| Hip circumference, cm | 103.3 ± 10.3 | 104.3 ± 11.0 | 106.1 ± 11.0 | 108.2 ± 12.3 |
| Smoking Status | ||||
| Never smoker | 365 (45.5) | 350 (42.8) | 379 (47.1) | 352 (43.1) |
| Former smoker | 315 (39.2) | 352 (43.0) | 333 (41.4) | 365 (44.7) |
| Current smoker | 123 (15.3) | 116 (14.2) | 93 (11.6) | 100 (12.2) |
| Cigarette pack-years (among ever-smokers) | 19.5 ± 22.8 | 19.1 ± 21.2 | 21.9 ± 24.5 | 24.4 ± 29.6 |
| Estimated GFR, mL/min/1.73 m2 | 88.2 ± 17.3 | 82.8 ± 16.1 | 80.1 ± 15.6 | 72.3 ± 18.6 |
| Estimated GFR Category | ||||
| Stage 1 | 346 (43.1) | 260 (31.8) | 197 (24.5) | 117 (14.4) |
| Stage 2 | 431 (53.7) | 511 (62.5) | 535 (66.6) | 503 (61.8) |
| Stage 3 | 25 (3.1) | 47 (5.8) | 71 (8.8) | 179 (22) |
| Stage 4 | 0 | 0 | 0 | 14 (1.7) |
| Stage 5 | 0 | 0 | 0 | 1 (0.12) |
| Creatinine, mg/dL | 0.88 ± 0.17 | 0.93 ± 0.19 | 0.96 ± 0.19 | 1.08 ± 0.39 |
| hs-CRP, mg/L | 3.9 ± 5.4 | 3.6 ± 5.7 | 3.3 ± 5.1 | 4.1 ± 6.2 |
| Interleukin-6, pg/mL | 1.4 ± 1.2 | 1.4 ± 1.0 | 1.6 ± 1.2 | 1.9 ± 1.3 |
| D-dimer, μg/L | 0.28 ± 0.36 | 0.32 ± 0.43 | 0.38 ± 1.0 | 0.53 ± 0.99 |
| PIIINP, μg/mL | 4.9 ± 1.2 | 5.2 ± 1.1 | 5.5 ± 1.2 | 6.4 ± 2.0 |
| Computed tomography | ||||
| Total imaged lung volume (gas + tissue), cm3 | 2768 ± 762.5 | 2813 ± 894.8 | 2796 ± 802.0 | 2804 ± 843.0 |
| Emphysema, % | 4.1 ± 4.5 | 4.3 ± 5.0 | 4.6 ± 5.0 | 4.5 ± 4.5 |
| Respiratory diseases | ||||
| Self-reported emphysema | 14 (1.7) | 11 (1.3) | 11 (1.4) | 14 (1.7) |
| Self-reported asthma | 92 (11.5) | 71 (8.7) | 70 (8.7) | 81 (9.9) |
Data presented as mean ± SD and frequency (percentage). All parameters collected at MESA baseline visit in years 2000–2002.
ICTP = collagen type I carboxy-terminal telopeptide, GFR = glomerular filtration rate, Stage 1 = eGFR ≥90mL/min/1.73 m2, Stage 2 = eGFR 60–89 mL/min/1.73 m2, Stage 3 = eGFR 30–59 mL/min/1.73 m2, Stage 4 = eGFR 15–29mL/min/1.73 m2, Stage 5 = eGFR < 15mL/min/1.73 m2, hs-CRP = high-sensitivity C-reactive protein, PIIINP = procollagen type III N-terminal propeptide.
Missing data are as follows: education (n = 5), smoking status (n = 1), asthma (n = 1), smoking pack-years (n = 44), estimated GFR (n = 7), creatinine (n = 7), hs-CRP (n = 16), interleukin-6 (n = 84), d-dimer (n = 12), PIIINP (n = 44).