Table 2.
Association of ICTP and PIIINP with high attenuation areas on CT.
| ICTP | PIIINP | |||||||
|---|---|---|---|---|---|---|---|---|
| % Increment in HAA% per SD Increment in ICTP | 95% CI | P Value | P for Interaction | % Increment in HAA% per SD Increment in PIIINP | 95% CI | P Value | P for Interaction | |
| Unadjusted | 2.5 | 1.5–3.6 | < 0.001 | 2.8 | 1.7–4.0 | < 0.001 | ||
| Minimally Adjusted Modela | 1.8 | 0.8–2.9 | < 0.001 | 2.0 | 0.9–3.1 | < 0.001 | ||
| Full Modelb | 1.3 | 0.2–2.4 | 0.02 | 0.96 | 0.06–1.9 | 0.04 | ||
| Stratified by gender | 0.97 | 0.28 | ||||||
| Male | 1.1 | −0.3–2.5 | 0.14 | 1.4 | 0.06–2.8 | 0.04 | ||
| Female | 1.0 | −0.4–2.5 | 0.17 | 0.3 | −0.9–1.5 | 0.64 | ||
| Stratified by smoking status | 0.88 | 0.43 | ||||||
| Ever-smoker | 1.7 | 0.1–3.4 | 0.04 | 0.6 | −0.8–2.1 | 0.40 | ||
| Never-smoker | 1.2 | −0.3–2.6 | 0.12 | 1.1 | −0.03–2.2 | 0.06 | ||
| Stratified by race/ethnicity | 0.23 | 0.97 | ||||||
| White | 1.2 | −0.5–2.9 | 0.17 | 0.8 | −0.5–2.1 | 0.22 | ||
| African American | 1.9 | 0.1–3.7 | 0.04 | 0.6 | −0.9–2.2 | 0.42 | ||
| Chinese American | −1.6 | −5.3–2.3 | 0.41 | 1.0 | −2.5–4.7 | 0.57 | ||
| Hispanic | 0.9 | −0.9–2.8 | 0.32 | 1.5 | −0.7–3.7 | 0.19 | ||
ICTP = collagen type I carboxy-termmal telopeptide, PIIINP = procollagen type III N-termmal propeptide, HAA = high attenuation areas.
All covariates measured at baseline examinations in 2000–2002. Analyses account for inverse probability weighting for case sampling. SD for ICTP was 1.33. SD for PIIINP was 1.54.
Model adjusted for total imaged lung volume, site and mA dose.
Full model adjusted for age, gender, race/ethnicity, educational attainment, height, body mass index, waist circumference, current smoker status, cigarette pack-years in ever-smokers, estimated glomerular filtration rate, high-sensitivity C-reactive protein, interleukin-6, d-dimer, study site, percent emphysema, mA dose, and total volume of imaged lung.