. Author manuscript; available in PMC: 2018 Dec 28.

Published in final edited form as: Respir Med. 2018 Jun 6;140:108–114. doi: 10.1016/j.rmed.2018.06.001

Table 3.

Association of ICTP and PIIINP with interstitial lung abnormalities on CT measured 10 years after biomarker assessment.

	ICTP				PIIINP

	Odds Ratio for ILA per SD Increment in ICTP	95% CI	P Value	P for Interaction	Odds Ratio for ILA per SD Increment in PIIINP	95% CI	P Value	P for Interaction
Unadjusted	1.17	1.00–1.37	0.05		0.87	0.72–1.04	0.13
Adjusted^a	1.05	0.88–1.26	0.55		0.87	0.70–1.08	0.22
Stratified by gender				0.98				0.69
Male	1.00	0.78–1.29	0.98		0.82	0.58–1.14	0.23
Female	1.07	0.82–1.39	0.64		0.90	0.67–1.21	0.49
Stratified by smoking status				0.20				0.13
Ever-smoker	1.17	0.94–1.45	0.17		0.98	0.76–1.28	0.90
Never-smoker	0.91	0.68–1.20	0.49		0.68	0.47–0.99	0.04
Stratified by race/ethnicity				0.25				0.45
White	0.80	0.57–1.12	0.20		0.63	0.43–0.92	0.02
African American	1.23	0.90–1.67	0.19		0.99	0.70–1.39	0.94
Chinese American	0.90	0.56–1.44	0.66		1.01	0.59–1.73	0.97
Hispanic	1.30	0.85–1.99	0.22		0.90	0.53–1.54	0.70

ICTP = collagen type I carboxy-terminal telopeptide, PIIINP = procollagen type III N-terminal propeptide, ILA = interstitial lung abnormalities.

All covariates measured at baseline examinations in 2000–2002. Analyses account for inverse probability weighting for case sampling. SD for ICTP was 1.33. SD for PIIINP was 1.54.

Adjusted for age, gender, race/ethnicity, current-smoker status and cigarette pack-years in ever-smokers.