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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Immunol. 2018 Nov 30;202(1):268–277. doi: 10.4049/jimmunol.1800454

Figure 5.

Figure 5.

IL-17 and NETs initiate liver injury exacerbated by administration of rIL-17 administration and modulated by administration of DNAse. (A) Serum ALT levels of mice after liver I/R in various treatment groups. In the presence of DNase, a NET inhibitor, the effects of rIL-17 were significantly ameliorated as evident by serum ALT levels. This correlated with decreased NET formation as seen in (B). (C and D) DyNA analysis of I/R livers of mice treated with DNAse reveal disassembly of the inflammatory network with a significant decrease in the number and complexity of inflammatory mediator connections compared to control mice.