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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Dev Biol. 2018 Jun 27;444(Suppl 1):S237–S251. doi: 10.1016/j.ydbio.2018.06.018

Figure 7. Cad6B proteolysis and its impact on EMT.

Figure 7.

Cad6B proteolysis from multiple proteases during EMT contributes several downstream regulatory inputs into the neural crest EMT program including loss of cell adhesion (downregulation of full-length Cad6B, (Schiffmacher et al., 2014)), transcriptional regulation of EMT genes including Snail2 (increased levels of Cad6B CTF2, (Schiffmacher et al., 2016), and breakdown of basement membranes contributing to delamination (increased levels of shed Cad6B NTFs).