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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: Sci Transl Med. 2018 Mar 14;10(432):eaai8524. doi: 10.1126/scitranslmed.aai8524

Fig. 6. Fas-controlled IL-1RA secretion regulates wound healing in mice.

Fig. 6.

(A) Scheme illustrating the gingival wound procedure in MRL/lpr mice and treatment with the IL-1RA drug anakinra. Full-thickness circular wounds were made in the palates of WT and MRL/lpr mice with a biopsy punch, and MRL/lpr mice were submucosally injected with either placebo (0.9% saline) or the IL-1RA drug anakinra (100 μg per mouse) 1 day after wound creation. (B) Representative macroscopic images and quantification of gingival wound area in WT and MRL/lpr mice after treatment with and without anakinra (n = 5). (C) Representative macroscopic images and quantification of dermal wound area in WT and MRL/lpr mice over time (n = 3). (D) Representative macroscopic images and quantification of dermal wound area in MRL/lpr mice treated with placebo (0.9% saline) or anakinra (500 μg per mice) injected 1 day after wound creation as in (A) (n = 3). **P < 0.01, ***P < 0.001. Error bars are means ± SD. Data were analyzed using one-way ANOVA with Bonferroni correction (B) or independent unpaired two-tailed Student’s t tests (C and D).