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. 2018 Dec;68(6):461–473. doi: 10.30802/AALAS-CM-18-000012

Figure 4.

Figure 4.

SIV infection of rhesus macaques is associated with increased right atrial (RA), right ventricular (RV), and mean pulmonary arterial pressures (mPAP) by 6 mo after infection. Systemic blood pressure measurements and right heart catheterization were performed on adult rhesus macaques at baseline (0 mo after infection), 6 mo after infection, and at study end (10–12 mo after SIV infection. (A) Mean systemic systolic and diastolic pressures remained in the normal range throughout SIV infection. (B) Right RA, (C) RV systolic pressure (RVSP), and (D) mean pulmonary artery pressure (mPAP) were significantly increased at 6 mo after infection and at study end. (E) A subset of SIV-infected macaques maintained mPAP in the normal range until 12 mo after infection (PAH–; n = 10). (F) Macaques with progressive PAH+ (P-PAH+) had significant elevation of mPAP at 6 mo after infection (n = 6) and at study end compared with baseline. (G) Macaques with transient PAH+ (T-PAH+) had a significant increase in mPAP at 6 mo after infection compared with baseline but decreased values by the terminal time point that did not return to baseline (P = 0.29).