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. Author manuscript; available in PMC: 2019 Dec 4.
Published in final edited form as: Int J Surg. 2018 Dec 3;60:283–290. doi: 10.1016/j.ijsu.2018.11.027

Figure 4: Deposition of C-RP (above) and amyloid A (below) in kidney tissue detected by IHC (magnification x200).

Figure 4:

(A, E) Expression of C-RP and amyloid A in a naive pig kidney (negative control); (B, F) Deposition of C-RP and amyloid A in the pig kidney in a baboon that experienced anaphylactic shock (without transplantation) (positive control). (C, G) Deposition of C-RP and amyloid A in a pig kidney xenograft that underwent hyperacute rejection after transplantation into a baboon (while receiving the IL-6R inhibitor, tocilizumab, and the TNF-α antagonist, etanercept) (positive control). (D, H) Deposition of C-RP and amyloid A in a representative pig kidney xenograft (in a baboon with rejection, while receiving tocilizumab). There is considerable deposition of amyloid A, but not C-RP, in the kidney. (I) Comparison of C-RP and amyloid A deposition in pig kidney xenografts in baboons (that were receiving tocilizumab). The difference in deposition is significant (***p<0.001).