Table 1:
Maintenance immunosuppressive (IS) therapy, survival (in days), and cause for euthanasia in baboons with pig kidney grafts
| Baboon Number |
Maintenance IS therapy | Survival (days) | Cause for euthanasia |
|---|---|---|---|
| Long survival group | |||
| B10815 | Anti-CD40mAb-based | 90 | AHXR |
| B9313 | Anti-CD40mAb-based | 136 | Systemic Infection |
| B17315 | Anti-CD40mAb-based | 237 | Systemic Infection |
| B17615 | Anti-CD40mAb-based | 260 | Systemic Infection |
| Short survival group | |||
| B17415 | Anti-CD40mAb-based | 12 | AHXR |
| B3115 | Anti-CD40mAb-based | 4 | Acute gastric dilatation |
| B14214 | Conventional therapy* | 32 | AHXR |
| B5415 | Conventional therapy* | 15 | AHXR |
| B15815 | Conventional therapy* | 12 | AHXR |
| B9015 | Conventional therapy* | 13 | AHXR |
| B14115 | Conventional therapy* | 1 | Hyperacute rejection |
*
Conventional therapy consisted of only FDA-approved agents (various combinations of CTLA4-Ig, tacrolimus, rapamycin, mycophenolate mofetil).
AHXR = acute humoral xenograft rejection.