Table 2. Human urine metabolome found in HPV+B vs HPV- and HPV+H vs HPV- groups.

#	Metabolite	RT	Fragment ions	VIP	HPV+B Adj P	HPV+H Adj P
1	Lactic acid	9.67	189, 233, 261	0.47	1.000	0.988
2	Acetic Acid	9.90	189, 219, 247	1.11	1.000	0.599
3	Glycine	10.69	147, 218, 246	0.47	1.000	0.993
4	2-Hydroxybutyric acid	11.24	189, 247, 275	0.55	1.000	0.988
5	Proline	11.55	184, 258, 328	0.22	0.987	0.993
6	Methylmalonic acid	11.83	147, 189, 289,	0.61	1.000	0.988
7	Urea	12.09	147, 231, 273	0.20	1.000	0.993
8	5-Oxoprolinate	13.18	75, 158, 186	1.82	0.303	0.009*
9	Threonine	13.27	130, 246, 290	0.61	1.000	0.983
10	Succinic acid	13.47	147, 189, 289,	0.57	1.000	0.955
11	Glycerol	15.07	171, 189, 347	0.35	1.000	0.993
12	5-Oxoproline	15.97	147, 272, 300	1.23	1.000	0.205
13	Glutaric acid	16.13	73, 147, 303	1.20	1.000	0.365
14	N-Acetylaspartic acid	16.65	73, 147, 346	1.65	0.575	0.024*
15	2-Butenoic acid	17.11	189, 247, 275	0.45	1.000	0.988
16	Hippuric acid	17.64	77, 105, 236	0.73	1.000	0.983
17	4-Hydroxybutyric acid	17.72	73, 147, 275	1.62	1.000	0.035*
18	4-Hydroxyphenylacetic acid	17.83	75, 205, 324	0.68	1.000	0.955
19	Erythronic acid	18.28	147, 289, 331	1.69	1.000	0.016*
20	2-Hydroxyglutaric acid	19.04	147, 207, 433	0.32	1.000	0.993
21	Glyceric acid	19.95	73, 231, 391	0.04	1.000	0.993
22	Aconitic acid	20.8	73, 147, 459	1.46	1.000	0.120
23	Citric acid	23.14	357, 459, 591	1.27	0.909	0.599
24	Uric acid	25.47	73, 567	1.11	1.000	0.685

RT—Retention time; VIP—Variable importance in projection scores identified via PLS-DA analysis for the PC1; Adj P–Adjusted P value determined using the Holm-Sidak method in comparison to HPV- group, α = 0.05.

*—indicate metabolite that matches selected criterion.