Table 4. Total cost (direct medical costs and the cost to the patient and caregiver) of DF by year and care setting.

Year	Care setting	Direct Medical Costs to the Healthcare System* US$ Average cost	Costs of dengue from the patient’s perspective (direct medical costs + direct nonmedical costs + productivity loss) US$ Average cost (95%CI)†	Totals US$ Average cost
2012	Outpatients	$6,064,041	$103,767 ($45,597–$163,834)	$6,167,807
	Hospitalized patients	$29,249,167	$4,599,711 ($2,229,167–$8,576,544)	$33,848,878
	Patients in ICU	$8,774,710	$228,898 ($148,052–$373,229)	$9,003,608
	Patients managed in all three settings	$44,087,918	$4,932,375 ($2,422,817–$9,113,607)	$49,020,293
2013	Outpatients	$10,346,634	$177,050 ($77,799–$279,538)	$10,523,684
	Hospitalized patients	$32,857,126	$5,167,097 ($2,504,141–$9,634,482)	$38,024,223
	Patients in ICU	$9,857,093	$257,133 ($166,314–$419,268)	$10,114,226
	Patients managed in all three settings	$53,060,853	$5,601,279	$58,662,133
2014	Outpatients	$4,635,180	$79,316 ($34,853–$125,230)	$4,714,497
	Hospitalized patients	$15,120,179	$2,377,793 ($1,152,355–$4,433,592)	$17,497,972
	Patients in ICU	$4,536,033	$118,327 ($76,534–$192,939)	$4,654,360
	Patients managed in all three settings	$24,291,393	$2,575,436	$26,866,829
2015	Outpatients	$6,391,957	$109,378 ($48,063–$172,693)	$6,501,335
	Hospitalized patients	$9,893,644	$1,555,870 ($754,024–$2,901,049)	$11,449,514
	Patients in ICU	$2,968,080	$77,426 ($50,079–$126,246)	$3,045,505
	Patients managed in all three settings	$19,253,681	$1,742,674	$20,996,355
2016	Outpatients	$4,470,974	$76,506 ($33,619–$120,794)	$4,547,480
	Hospitalized patients	$38,375,956	$1,058,774 ($513,116–$1,974,173)	$39,434,730
	Patients in ICU	$2,019,787	$52,688 ($34,079–$85,911)	$2,072,476
	Patients managed in all three settings	$44,866,717	$1,187,969	$46,054,686

* PAATI methodology;

^†costs reported by the patients, a bootstrap analysis was performed to assess variability