Fig 5. Cellular strain profiles and corresponding responses for simulations shown in Fig 4.

(A) Estimated cellular strain profiles derived from tendon strain profiles predicted by hindlimb model in OpenSim. (B) Cellular alignment response curve generated by model of stress fiber dynamics (gray line, same as Fig 3) and operating points on that curve for unloading (light color) and loading (dark color) conditions in both unrepaired (blue) and suture-repaired (red) tendons. (C) Response curve showing the effect of mean strain on fibroblast collagen synthesis rate (gray line, same as Fig 3) and circles indicating the operating points for the different cases simulated.