Figure 7. Model for musculoskeletal and connective tissue relationships during murine neck development.
See also Figure 7—figure supplement 1. (A, C) CPM (pink), anterior somites (red) and more posterior somites (violet) muscles are defined by three distinct myogenic programs. (B) Note that the cucullaris develops in a NC domain (blue dots), but is excluded from the postcranial LPM (yellow dots). (C) Dual NC/LPM origin of trapezius connective tissue is indicated in (a). NC contribution to connective tissue extends to tongue and anterior infrahyoid musculature (b). (D) Mixed origins of muscle connective tissues at the head-trunk-limb interface. Example of representative muscles: (a) masseter, (b) spinalis dorsi, (c) deltoid. atp, acromiotrapezius; ccl, cucullaris; CPM, cardiopharyngeal mesoderm; epm, epaxial neck musculature; hpm, hypaxial neck musculature; hy, hyoid bone; LPM, postcranial lateral plate mesoderm; NC, neural crest; PA1-2, pharyngeal arches 1–2; PM, paraxial mesoderm; stm, sternocleidomastoid; stp, spinotrapezius; tc, thyroid cartilage.