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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: Arch Toxicol. 2014 Apr 8;88(8):1491–1502. doi: 10.1007/s00204-014-1234-6

Fig. 5.

Fig. 5

Metabolomics reveals that PPARα mediated gemfibrozil-induced hepatotoxicity. The therapeutic role of gemfibrozil can be explained by PPARα-induced expression of target genes involved in fatty acid β-oxidation. PPARα-dependent regulation of the metabolic genes involved in the LPC and bile acid metabolism and/or transport result in alteration of downstream metabolic pathways