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Synthesis of protected oxy-lysine. a) ethylchloroformate, N-methylmorpholine, THF, −10°C; b) NaBH4, MeOH, 0°C; c) methanesulfonylchloride, Et3N, DCM, 0°C; d) N-hydroxyphthalimide, DBU, DMF, 0°C-rt; e) methylhydrazine, DCM, 0°C; f) Boc2O, Et3N, THF, rt; g) H2/Pd/C, rt, FmocOsu, NaHCO3, dioxane, H2O, rt.
