Table 3.
Risk factors for LRTD without prior URTI (N=121)
| Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95% CI | P Value | |
| Age at PIV infection | ||||||
| ≤ 20 | 0.25 | 0.1–1.3 | 0.09 | |||
| 21–60 | 0.44 | 0.1–1.5 | 0.19 | |||
| > 60 | 1.00 | |||||
| Cell source | ||||||
| PBSC | 1.00 | 1.00 | ||||
| BM or CB | 0.39 | 0.2–0.8 | 0.012 | 0.47 | 0.1–1.7 | 0.25 |
| %FEV1/FVC pre PIV infection | ||||||
| ≥ 70 | 1.00 | |||||
| < 70 | 2.25 | 0.9–5.6 | 0.08 | |||
| %TLC pre PIV infection | ||||||
| ≥ 80 | 1.00 | 1.00 | ||||
| < 80 | 3.41 | 1.1–10.3 | 0.030 | 5.56 | 1.1–25.0 | 0.036 |
| Days between transplantation and PIV infection | ||||||
| ≤ 30 | 0.92 | 0.4–2.4 | 0.87 | |||
| 31–100 | 0.42 | 0.2–1.0 | 0.047 | |||
| > 100 | 1.00 | |||||
| Inpatient at diagnosis | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 3.44 | 1.6–7.3 | 0.001 | 1.61 | 0.4–6.0 | 0.48 |
| Diagnosis on weekday | ||||||
| No | 1.00 | |||||
| Yes | 0.51 | 0.2–1.5 | 0.21 | |||
| Documented URTI symptom at diagnosis | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 0.19 | 0.1–0.4 | <.001 | 0.17 | 0.0–0.7 | 0.017 |
| LRTD symptom at diagnosis | ||||||
| No | 1.00 | |||||
| Yes | 3.37 | 1.1–10.3 | 0.033 | |||
| PIV type | ||||||
| PIV-1, 2, 4 | 1.00 | |||||
| PIV-3 | 0.26 | 0.1–1.0 | 0.049 | |||
| Co-pathogen | ||||||
| No / Blood alone | 1.00 | 1.00 | ||||
| Upper respi ratory tract | 0.38 | 0.0–3.5 | 0.40 | 0.41 | 0.0–40.1 | 0.24 |
| Lower respi ratory tract | 14.60 | 4.1–52.0 | <.001 | 43.70 | 6.0–321 | 0.006 |
| Oxygen use at diagnosis | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 10.30 | 4.4–24.5 | <.001 | 9.51 | 2.2–41.2 | 0.003 |
| Steroid dose before diagnosis | ||||||
| No | 1.00 | |||||
| < 1 mg/kg | 1.80 | 0.7–4.7 | 0.23 | |||
| 1–2 mg/kg | 0.38 | 0.2–0.9 | 0.034 | |||
| > 2 mg/kg | 1.96 | 0.3–11.3 | 0.45 | |||
All variables in Supplemental Table 1 were used for the univariate analysis. Only variables with p < 0.1 in any analysis except diagnosis on weekday are shown in this table. The most informative multivariable model is shown here and additional models with different combinations of risk factors did not yield other factors that remained after adjustment.
Abbreviations: PBSC, periperal blood stem cell; BM, bone marrow; CB, cord blood; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity