Figure 4.

Numerous associations have been found between specific mitochondrial mutations or haplogroups and longevity or disease. (A) In the control region, the C to T mutation at position 150 has been reported to correlate with longer lifespan. Mutations at positions 3243, 3316 and 11778 are associated with diabetes and cardiomyopathy, diabetes and Parkinson’s disease, respectively. Three common mutations that can cause Leber’s hereditary optic neuropathy are indicated (triangles). A common deletion of nearly 5 kb can contribute to multiple pathologies.(B) Several mitochondrial haplogroups have been found to correlate with either longer lifespan or disease, or in the case of haplogroup J, with both.