Table 1.
The effects on lifespan of knockdown (null), knockout (KO) and transgenic overexpression (OE) of mitochondrial oxidant scavenging and redox enzymes in C. elegans, D. melanogaster and M. musculus are summarized. In the two cases where a transgenic model was created but lifespan was not assayed, these studies are referenced.
| Effects of Mitochondrial Redox Enzyme Manipulation on Lifespan | |||
|---|---|---|---|
| C. elegans | D. melanogaster | M. musculus | |
| SOD2 null | Life extension [68] | Early lethality [64] | Lethal [65, 66] |
| SOD2 KD | No effect [210] | Life reduction [211] | No effect [70] |
| SOD2 OE | Life extension [212] | Life extension [72] | No effect [71] |
| GPx4 null | - | - | Lethal [213] |
| GPx4 KD | - | - | Life extension [76] |
| GPx4 OE | - | - | - |
| PRX3 null | - | - | Not reported [214] |
| PRX3 KD | - | - | - |
| PRX3 OE | - | - | - |
| TRX2 null | No effect [215] | - | Lethal [216] |
| TRX2 KD | - | - | Life reduction [60] |
| TRX2 OE | - | - | - |
| TXNRD2 null | No effect [215] | Lethal [217] | - |
| TXNRD2 KD | - | - | - |
| TXNRD2 OE | Not reported [215] | Life extension [84] | - |