Figure 5. T_FH signature is up-regulated in autoimmune and inflammatory diseases.

(A) Body weight of Rag1^‒/‒ recipient mice after receiving 6×10⁵ purified CD4⁺ T cells from LckCre⁺Irf8^wt/wt (n = 5) or Lck-Cre⁺Irf8^fl/fl (n = 5) mice with CD19⁺B220⁺ B cells from WT mice. (B) Histological staining of colon tissues and histology score of Rag1^‒/‒ recipients of LckCre⁺Irf8^wt/wt CD4⁺ T cells (n = 5) and those of Lck-Cre⁺Irf8^fl/fl CD4⁺ T cells (n = 5). (C) The percentages of CXCR5⁺ICOS⁺, CXCR5⁺PD-1⁺ and CXCR5⁺Bcl6⁺ CD4⁺ T cells were compared between Rag1^‒/‒ recipients of Lck-Cre⁺Irf8^wt/wt CD4⁺ T cells (n = 5) and those of Lck-Cre⁺Irf8^fl/fl CD4⁺ T cells (n = 5) and WT as control (n=5). Results shown are representative of three independent experiments. Data are given as means ± SD.