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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Ann N Y Acad Sci. 2018 Jun 28;1442(1):79–90. doi: 10.1111/nyas.13914

Figure 2.

Figure 2

P2X7R expression in response to mechanical loading in Panx1−/− mice. (A) Expression of P2X7R in non-loaded and loaded Panx1−/− compared to age-matched non-loaded wildtype (dotted line) after 2 or 4 weeks of loading (treadmill running). (B) Expression of P2X7R in loaded Panx1−/− compared to age-matched non-loaded Panx1−/− (dotted line) after 2 or 4 weeks of loading. (C) Representative western blots for P2X7R from 2 weeks and 4 weeks loaded Panx1−/− mice (positive symbol) and non-loaded age match controls (negative symbol). Protein levels were first normalized with the respective β-actin loading control, and then with the age-matched non-loaded wildtype levels. Comparisons were performed using one-way ANOVA followed by Tukey’s multiple comparison test. For the comparison between Panx1−/− non-loaded vs. age-matched loaded, an unpaired t-test was used followed by Mann-Whitney comparison test. Loading duration group: n = 5 (2 weeks), n = 6 (4 weeks). Data presented as means ± SD.