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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Ann N Y Acad Sci. 2018 Jun 28;1442(1):79–90. doi: 10.1111/nyas.13914

Table 1.

Histological studies showing load-induced changes in femoral midshaft of 4-week loaded vs. non-loaded wildtype and Panx1−/− bones.

Parameters Wildtype Panx1−/−
non-loaded
(n = 6)		 loaded
(n = 6)		 non-loaded
(n = 7)		 loaded
(n = 6)
Body weight (g) 28.8 ± 1.5 26.8 ± 2.08 26.3 ± 1.44 25.1 ± 2.02
Tt.Ar (mm2) 1.71 ± 0.09 1.94 ± 0.09* 1.89 ± 0.04* 1.75 ± 0.15#
Ct.B.Ar (mm2) 0.76 ± 0.05 0.89 ± 0.08** 0.91 ± 0.05** 0.78 ± 0.10#
Ct.B.Ar / Tt.Ar 0.45 ± 0.02 0.45 ± 0.04 0.48 ± 0.02 0.44 ± 0.02
Ma.Ar (mm2) 0.94 ± 0.05 1.08 ± 0.07** 0.99 ± 0.04 0.96 ± 0.05
Ct.Th (µm) 194.1 ± 5 202.3 ± 16 206.2 ± 8 199.0 ± 16
J (mm4) 0.35 ± 0.03 0.46 ± 0.04** 0.41 ± 0.02 0.39 ± 0.07
Ix (mm4) 0.12 ± 0.01 0.15 ± 0.02* 0.14 ± 0.01 0.13 ± 0.03
Iy(mm4) 0.24 ± 0.02 0.31 ± 0.04** 0.27 ± 0.02 0.26 ± 0.04
*

P<0.05,

**

P<0.01, comparisons with respect to non-loaded wildtype using one-way ANOVA followed by Tukey’s multiple comparison test.

#

P<0.05, comparison between loaded vs. non-loaded Panx1−/− using unpaired t-test followed by Mann-Whitney test.

n = number of animals/group. Total area (Tt.Ar), cortical bone area (Ct.B.Ar), marrow area (Ma.Ar), cortical thickness (Ct.Th), polar moment of inertia (J) and area moment of inertia (Ix and Iy) are presented as the means ± SD.