. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Ann N Y Acad Sci. 2018 Jun 28;1442(1):79–90. doi: 10.1111/nyas.13914

Table 2.

Dynamic histomorphometric studies showing load-induced changes in femoral midshaft of 2-week loaded vs. non-loaded wildtype and Panx1^−/− bones.

Parameters	Wildtype		Panx1^−/−
Parameters	non-loaded (n = 5)	loaded (n = 5)	non-loaded (n = 4)	loaded (n = 4)

Ps.MS/BS (%)	17.5 ± 3.9	29.9 ± 4.9^**	23.7 ± 4.9	15.5 ± 1.2^#
Ps.MAR (µm/day)	1.4 ± 0.2	1.6 ± 0.2	1.5 ± 0.1	1.3 ± 0.2
Ps.BFR/BS (µm³/µm²/day)	0.25 ± 0.1	0.47 ± 0.1^**	0.34 ± 0.07	0.20 ± 0.02^#
Ec.MS/BS (%)	34.7 ± 8.7	32.9 ± 6.2	34.6 ± 4.9	40.1 ± 2.2
Ec.MAR (µm/day)	1.6 ± 0.4	1.6 ± 0.5	1.1 ± 0.3	1.4 ± 0.1
Ec.BFR/BS (µm³/µm²/day)	0.58 ± 0.3	0.53 ± 0.3	0.38 ± 0.13	0.56 ± 0.06

^**

P<0.01, comparisons with respect to age-matched non-loaded wildtype;

P<0.05, loaded vs. age-matched non-loaded Panx1^−/−; one-way ANOVA followed by Tukey’s multiple comparison test.

Periosteal mineralizing surface (Ps.Ms/Bs), periosteal mineral apposition rate (Ps.MAR), periosteal bone formation rate (Ps.BFR/BS), endocortical mineralizing surface (Ec.Ms/Bs), endocortical mineral apposition rate (Ec.MAR), and endocortical bone formation rate (Ec.BFR/BS) are presented as means ± SD.