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Immune response of pentavalent synthetic glycoconjugate vaccine sPCV5 in rabbits. NZW rabbits (n = 3–6) were vaccinated s.c. with sPCV5, the marketed vaccines Prevnar13 or Synflorix, or the coformulated vaccines Prevnar13+ST2+ST8 or Synflorix+ST2+ST3+ST8. Polysaccharide-specific ST2, ST3, ST5, ST8, and ST14 antibody levels in rabbit sera were evaluated by ELISA at the endpoint titer dilution. Each dot represents an individual rabbit immune response; data were analyzed by an ANOVA test.
