Fig. 5.

Synthetic glycoconjugate vaccine sPCV5 induces long-term memory response. NZW rabbits (n = 3–6) were immunized four times (days 0, 14, 28, and 119) s.c. with sPCV5, Prevnar13+ST2+ST8, Synflorix+ST2+ST3+ST8 as well as positive controls Prevnar13 and Synflorix. Serum was collected 1 wk after each immunization. Polysaccharide-specific antibody titers were analyzed by ELISA. Plates coated with CPSs corresponding to (A) ST2, (B) ST3, (C) ST5, (D) ST8, and (E) ST14. Data represented as mean ± SD, duplicate determinations.