Frequency of and haplotype structure of the SLC24A5 rs1426654 allele. (A) Frequency map of the derived rs1426654*A allele in Africa and the Near East. Asterisks denote the locations of the ≠Khomani San and Nama samples in this study. Other populations are represented by gray cross-hatches. Color gradients correspond to the binned frequency spectrum (SI Appendix, Table S1). The equator is indicated as the dashed line. (B and C) Haplotype networks were constructed by a median-joining algorithm. Colors denote Europeans (CEU, red), Bantu-speaking Luhya (LWK, purple), and KhoeSan (SAN, yellow). Node size is proportional to number of shared haplotypes, and branch length reflects number of mutations between nodes. Arrow points to the cluster of derived haplotypes. Haplotype network of SLC24A5 is for (B) all individuals carrying either the ancestral or derived allele and (C) individuals who are homozygous derived at rs1426654.