Fig. 3.

Simulation of KhoeSan demographic history with positive selection. (A) Demographic schematic to introduce the derived SLC24A5 into the KhoeSan under a complex four-population model. An alternative model assumes no contribution from eastern African pastoralists (SI Appendix, Fig. S5). Relative timing and migration rates are noted as t and m, and their footnotes denote the initials of population: E, Europeans; EP, Eastern Pastoralists; B, Bantu; and K, KhoeSan (SI Appendix, Table S2). For simplicity, the frequency in Luhya is set to 0, as they carry a low frequency of the derived allele, which introduces a negligible number of derived copies during migration. (B) Divergence among populations that have contributed gene flow to KhoeSan.