Table 1.
tMRCA estimates of rs1426654*A
| Source | Method | Haplotype sample size (N) | tMRCA,* kya |
| This study | ρ† | KhoeSan (357) | 32 (±7) |
| Homozygous KhoeSan (148) | 22 (±5) | ||
| CEU (198) | 15 (±3) | ||
| LWK (15) | 101 (±20) | ||
| This study | starmrca | KhoeSan (860) | 22 [17 to 28] |
| Homozygous KhoeSan (462) | 16 [12 to 20] | ||
| CEU (198)‡ | 13 [7 to 33] | ||
| LWK (198) | 27 [17 to 37] | ||
| Beleza et al. (21) | ABC (microsatellites) | Europeans | 11 [1 to 55] |
| Nakagome et al. (44) | ABC | Europeans | 35 [25 to 52] |
*
Generation time is assumed to be 30 y. Uncertainty in parameter estimates are indicated as (±SE) or [95% C.I.].
†
Only haplotypes that carry the derived allele are included.
‡
LWK haplotypes that carry the ancestral allele at rs1426654 are used as background haplotypes.
starmrca, starmrca software package (Materials and Methods and ref. 28).