Table 1.
Structural mapping of the mutations that trap GLIC in a LC conformation
| Variant | Location | Conformation (phenotype) | Note |
| Q193C+MMTS | Pre-M1 | LC1 (loss-of-function) | Present study |
| Q193L | Pre-M1 | LC1 (loss-of-function) | Present study |
| Q193M | Pre-M1 | LC1 (loss-of-function) | Present study |
| Y197F-P250C | Pre-M1 | LC1 (wild-type phenotype) | Present study |
| I201W- E243C | Pre-M1 | LC2 (nonfunctional) | Present study |
| H235F (H11′F) | Upper M2 | LC1 (nonfunctional) | PDB ID code 3TLT |
| H235Q (H11′Q) | Upper M2 | LC (loss-of-function) | PDB ID code 5NJY |
| N239C (N15′C) | Upper M2 | LC (loss-of-function) | PDB ID code 5NKJ |
| E243G (E19′G) | Upper M2 | LC2 (nonfunctional) | Present study |
| E243P (E19′P) | Upper M2 | LC2 (nonfunctional) | PDB ID code 3TLS |
| P247G (P23′G) | M2-M3 loop | LC2 (loss-of-function) | PDB ID code 5HEG |
| T249A (T25′A) | M2-M3 loop | LC1 (nonfunctional) | PDB ID code 4LMJ |
| Y251A (Y27′A) | M2-M3 loop | LC1 (nonfunctional) | PDB ID code 4MLM |
| Wild-type 10*His | C-terminal 10*His | LC and open coexist | PDB ID code 4NPP |
| K33C-T20′C | Loop2 and M2-M3 loop | LC1 (nonfunctional) | PDB ID code 3UU3 |
| K33C-N21′C | Loop2 and M2-M3 loop | LC2 (nonfunctional) | PDB ID code 3TLW |
| K33C-L22′C | Loop2 and M2-M3 loop | LC3 (loss-of-function) | PDB ID code 3TLV |
| K33C-K24′C | Loop 2 and M2-M3 loop | LC1 (nonfunctional) | PDB ID code 3TLU |