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. 2018 Dec 12;115(52):E12313–E12322. doi: 10.1073/pnas.1814705115

Fig. 3.

Fig. 3.

p38α deficiency in DCs suppresses inflammatory responses by promoting Tr1 differentiation. (A–C) Wild-type (WT) and p38αΔDC mice were supplied with 7 d of 3% DSS solution followed with 2 d of normal water or 9 d of normal water. Relative expression of inflammation-related genes in colon tissue was examined (n = 5; A). Cytokine secretion in colon tissue was determined in DSS-treated mice (n = 7–8; B). The percentages of Tr1 cells and IL-10+ Treg cells in colon tissue of DSS-treated mice were analyzed (C). (D and E) WT and p38αΔDC mice were supplied with 7 d of 2.5% DSS solution followed with normal drinking water and injected with αIL-10R or isotype at days 3 and 5 for analyses of body weight (D) and relative expression of inflammation-related genes in colon tissue (E; n = 6). Data represent mean ± SEM. Two-way ANOVA with Bonferroni posttest (A, D, and E) and two-tailed Student’s t test (B). Results were replicated (n = 3 experiments). *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.