Fig. 6.
The effect of DC p38α on colitis-associated tumorigenesis is in an IL-27–dependent manner. Wild-type (WT), p38αΔDC, IL-27ΔDC, and DKO mice were injected with 10 mg/kg AOM at day 0 and then given three cycles of 5 d of 2% DSS solution (n = 6). Mice were killed at day 80. (A) Colon length. (B) Tumor numbers. (C) Photograph of colon tumors. (D) Tumor diameter. (E) Tumor load. Data represent mean ± SEM. One-way ANOVA with Tukey’s posttest (A, B, D, and E). Results were replicated (n = 3 experiments). *P < 0.05; **P < 0.01; ns, not significant.